Article (Scientific journals)
Prognostic relevance of epilepsy at presentation in glioblastoma patients.
Berendsen, Sharon; Varkila, Meri; Kroonen, Jerome et al.
2016In Neuro-Oncology
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Keywords :
epilepsy; glioblastoma; prognosis; survival; valproic acid
Abstract :
[en] BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due to early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship between survival and epilepsy at presentation, early diagnosis, and antiepileptic drug therapy in glioblastoma patients. METHODS: Multivariable Cox regression was applied to survival data of 647 consecutive patients diagnosed with de novo glioblastoma between 2005 and 2013 in order to investigate the association between epilepsy and survival in glioblastoma patients. In addition, we quantified the association between survival and valproic acid (VPA) treatment. RESULTS: Epilepsy correlated positively with survival (HR: 0.75 (95% CI: 0.61-0.92), P < .01). This effect is independent of age, sex, performance status, type of surgery, adjuvant therapy, tumor location, and tumor volume, suggesting that this positive correlation cannot be attributed solely to early diagnosis. For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment. CONCLUSION: Epilepsy is an independent prognostic factor for longer survival in glioblastoma patients. This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment.
Disciplines :
Genetics & genetic processes
Author, co-author :
Berendsen, Sharon
Varkila, Meri
Kroonen, Jerome
Seute, Tatjana
Snijders, Tom J.
Kauw, Frans
Spliet, Wim G. M.
Willems, Marie
Poulet, Christophe  ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Broekman, Marike L.
Bours, Vincent ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Robe, Pierre ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Prognostic relevance of epilepsy at presentation in glioblastoma patients.
Publication date :
2016
Journal title :
Neuro-Oncology
ISSN :
1522-8517
eISSN :
1523-5866
Publisher :
Oxford University Press
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Available on ORBi :
since 11 January 2016

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