Article (Scientific journals)
Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse
Hartmann, Stephanie; Hasenkamp, Natasha; Mayer, Jens et al.
2015In BMC Genomics, DOI 10.1186/s12864-015-1766-z
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Abstract :
[en] Background: Endogenous Q1 murine leukemia retroviruses (MLVs) are high copy number proviral elements difficult to comprehensively characterize using standard low throughput sequencing approaches. However, high throughput approaches generate data that is challenging to process, interpret and present. 8 9 10 Results: Next generation sequencing (NGS) data was generated for MLVs from two wild caught Mus musculus domesticus (from mainland France and Corsica) and for inbred laboratory mouse strains C3H, LP/J and SJL. Sequence reads were grouped using a novel sequence clustering approach as applied to retroviral sequences. A Markov cluster algorithm was employed, and the sequence reads were queried for matches to specific xenotropic (Xmv), polytropic (Pmv) and modified polytropic (Mpmv) viral reference sequences. 11 12 13 14 15 Conclusions: Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to the presence of similar sequence across many different proviral loci. The results did not correlate with variation in the major MLV receptor Xpr1, which can restrict exogenous MLVs, suggesting that endogenous MLV distribution may reflect gene flow more than past resistance to infection.
Disciplines :
Zoology
Author, co-author :
Hartmann, Stephanie
Hasenkamp, Natasha
Mayer, Jens
Michaux, Johan  ;  Université de Liège > Département des sciences de la vie > Génétique et physiologie des microalgues
Morand, Serge
Mazzoni, Camilla
Roca, Alfred L.
Greenwood, Alex
Language :
English
Title :
Endogenous murine leukemia retroviral variation across wild European and inbred strains of house mouse
Publication date :
2015
Journal title :
BMC Genomics
eISSN :
1471-2164
Publisher :
BioMed Central
Volume :
DOI 10.1186/s12864-015-1766-z
Peer reviewed :
Peer Reviewed verified by ORBi
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since 06 January 2016

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