Article (Scientific journals)
Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
Xu, Xuewen; Ectors, Fabien; Davis, Erica E. et al.
2015In PLoS ONE, 10 (10), p. 0140594
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Abstract :
[en] The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep.
Disciplines :
Genetics & genetic processes
Author, co-author :
Xu, Xuewen
Ectors, Fabien  ;  Université de Liège > GIGA-Technology platforms : Plate-forme transgénique
Davis, Erica E.
Pirottin, Dimitri ;  Université de Liège > Département des sciences fonctionnelles (DSF) > Département des sciences fonctionnelles (DSF)
Cheng, Huijun ;  Université de Liège - ULiège > Doct. sc. vété. (Bologne)
Farnir, Frédéric  ;  Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Hadfield, Tracy
Cockett, Noelle
Charlier, Carole  ;  Université de Liège > Département des productions animales (DPA) > GIGA-R : Génomique animale
Georges, Michel  ;  Université de Liège > Département des productions animales (DPA) > GIGA-R : Génomique animale
Takeda, Haruko ;  Université de Liège > GIGA-Research
Language :
English
Title :
Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
Publication date :
16 October 2015
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, United States - California
Volume :
10
Issue :
10
Pages :
e0140594
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 December 2015

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