Article (Scientific journals)
Penicillin-binding proteins: evergreen drug targets.
Frère, Jean-Marie; Page, Malcolm G. P.
2014In Current Opinion in Pharmacology, 18, p. 112-9
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Keywords :
Anti-Bacterial Agents/pharmacology; Penicillin Resistance/physiology; Penicillin-Binding Proteins/antagonists & inhibitors/chemistry/metabolism; Protein Conformation; beta-Lactams/pharmacology
Abstract :
[en] The penicillin-binding proteins (PBPs) are well known targets for the beta-lactam antibiotics. They continue to be a focus of interest for pharmaceutical design, as exemplified by the number of new agents under clinical investigation as well as novel experimental molecules. Considerable advances have been made in understanding the structure and function of this family of enzymes, through high-resolution structural studies and mechanistic studies in solution. These studies have thrown light on role of the high molecular mass PBPs in mediating beta-lactam resistance, although much work remains to be done to enable a full description of the mechanisms by which these proteins modulate their sensitivity towards beta-lactams while retaining their essential activity in cell wall biosynthesis.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Frère, Jean-Marie ;  Université de Liège - ULiège
Page, Malcolm G. P.
Language :
English
Title :
Penicillin-binding proteins: evergreen drug targets.
Publication date :
2014
Journal title :
Current Opinion in Pharmacology
ISSN :
1471-4892
eISSN :
1471-4973
Publisher :
Elsevier, Netherlands
Volume :
18
Pages :
112-9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 Elsevier Ltd. All rights reserved.
Available on ORBi :
since 22 December 2015

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