Article (Scientific journals)
(18)F-FPRGD2 PET/CT imaging of musculoskeletal disorders.
WITHOFS, Nadia; CHARLIER, Edith; Simoni, Paolo et al.
2015In Annals of Nuclear Medicine, 29 (10), p. 839-47
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Keywords :
Discopathy; Integrin; Joint; Osteoarthritis; PET; RGD
Abstract :
[en] OBJECTIVE: This work reports on musculoskeletal uptake of (18)F-FPRGD2, targeting the integrin alphavbeta3, in patients who had undergone (18)F-FPRGD2 positron emission tomography combined with computed tomography (PET/CT) for oncologic purposes. METHODS: Whole-body (18)F-FPRGD2 PET/CT images of 62 cancer patients were retrospectively reviewed to detect foci of musculoskeletal (18)F-FPRGD2 uptake. For 37 patients, a FDG PET/CT performed in clinical settings was available. In each joint with an abnormal uptake, the maximum standardized uptake value (SUVmax) was estimated. RESULTS: A total of 260 musculoskeletal foci of (18)F-FPRGD2 uptake were detected. Most common sites of uptake were joints and discs (n = 160; 61.5 %), entheses (osteotendinous and osteoligamentous junctions; n = 55; 21.2 %) and recent fractures (n = 18; 6.9 %). In addition, 27 (10.4 %) miscellaneous foci were detected. Out of the 146 lesions for which a FDG PET was available, 63 % showed both (18)F-FPRGD2 and FDG uptake, 33.6 % did not show FDG avidity and 3.4 % showed only FDG uptake. The uptake intensity of the 92 lesions positive with (18)F-FPRGD2 and FDG was similar with both radiopharmaceuticals, but the target-to-background (blood pool or muscle) ratios were significantly higher with (18)F-FPRGD2 than with FDG (p < 0.0001). CONCLUSION: The (18)F-FPRGD2 uptake in joints, spine degenerative diseases and tendons was highly prevalent in our population. Up to one-third of (18)F-FPRGD2 foci showed no FDG uptake suggesting that (18)F-FPRGD2 signal may not be related to inflammatory angiogenesis only.
Disciplines :
Rheumatology
Radiology, nuclear medicine & imaging
Author, co-author :
WITHOFS, Nadia ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de médecine nucléaire et imagerie onco
CHARLIER, Edith ;  Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
Simoni, Paolo
Alvarez-Miezentseva, Victoria
Mievis, Frédéric ;  Université de Liège > Centre de recherches du cyclotron
Giacomelli, Fabrice ;  Université de Liège > Centre de recherches du cyclotron
Mella, Christine ;  Université de Liège > Centre de recherches du cyclotron
Gambhir, Sanjiv S.
Malaise, Olivier ;  Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie
DE SENY, Dominique ;  Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
MALAISE, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Rhumatologie
HUSTINX, Roland  ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de médecine nucléaire et imagerie onco
Language :
English
Title :
(18)F-FPRGD2 PET/CT imaging of musculoskeletal disorders.
Publication date :
2015
Journal title :
Annals of Nuclear Medicine
ISSN :
0914-7187
eISSN :
1864-6433
Publisher :
Japanese Society of Nuclear Medicine/Nihon Kaku Igakkai, Japan
Volume :
29
Issue :
10
Pages :
839-47
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 December 2015

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