Reference : The NF-κ B-independent functions of IKK subunits in immunity and cancer
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
The NF-κ B-independent functions of IKK subunits in immunity and cancer
[en] Les fonctions des IKKs indépendantes de NF-kB dans le cancer et l'immunité
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Trends in Cell Biology
Elsevier Science
Yes (verified by ORBi)
United Kingdom
[en] IKK ; NF-kB ; Cancer
[en] The IKK complex is involved in transcriptional activation by phosphorylating the inhibitory molecule IkBa, a modification that triggers its subsequent degradation, allowing activation of NF-kB. Importantly, recent reports indicate that multiple cytoplasmic and nuclear proteins distinct from the NF-kB/IkB proteins are phosphorylated by the catalytic subunits of the IKK complex, IKKa or IKKb. Here we describe how the IKK subunits can play crucial roles in allergy, inflammation, immunity by targeting proteins such as SNAP23 and IRF7 but also in cancer by phosphorylating key molecules such as p53, TSC1 and FOXO3a through NF-kB-independent pathways. Thus, these recent findings considerably widen the biological roles played by these kinases and suggest that a full understanding of the biological roles played by IKKa and IKKb requires an exhaustive characterization of their substrates.
Unit of Signal Transduction, GIGA-R
FNRS, TELEVIE, ARC, Fédération BElge contre le cancer, Fonds Léon Frédéricq, CAC
Researchers ; Professionals ; Students

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