Recent advances in BLV research

[en] Different animal models have been proposed to investigate the mechanisms of HTLV-induced pathogenesis: rats, transgenic and NOD-SCID/γcnull (NOG) mice, rabbits, squirrel monkeys, baboons and macaques. These systems indeed provide useful information but have intrinsic limitations such as lack of disease relevance, species specificity or inadequate immune response. Another strategy based on a comparative virology approach is to characterize a related pathogen and to speculate on possible shared mechanisms. In this perspective, bovine leukemia virus (BLV), another member of the deltaretrovirus genus, is evolutionary related to HTLV-1. BLV induces lymphoproliferative disorders in ruminants providing useful information on the mechanisms of viral persistence, genetic determinants of pathogenesis and potential novel therapies.

Disciplines :

Oncology

Author, co-author :

Barez, Pierre-Yves ; Université de Liège - ULiège > Doct. sc. agro. & ingé. biol.

De Brogniez, Alix ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Carpentier, Alexandre ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Gazon, Hélène ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Gillet, Nicolas ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Gutiérrez, Gerónimo

Hamaïdia, Malik ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Jacques, Jean-Rock ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Perike, Srikanth ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Neelature Sriramareddy, Sathyanarayana ; Université de Liège - ULiège > Form. doct. sc. agro. & ingé. biol.

More authors (5 more)

Language :

English

Title :

Recent advances in BLV research

Publication date :

24 November 2015

Journal title :

Viruses

eISSN :

1999-4915

Publisher :

MDPI, Basel, Switzerland

Volume :

Issue :

Pages :

6080-6088

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.mdpi.com/1999-4915/7/11/2929

Available on ORBi :

since 24 November 2015

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Bibliography

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