Article (Scientific journals)
Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis.
GAUDIN, Elise; SEIDEL, Laurence; Bacevic, Miljana et al.
2015In Journal of Clinical Periodontology
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Keywords :
Anti-resorptive drug; Bisphosphonates; Dental extraction; Meta-analysis; Osteonecrosis of the jaw; Systematic review
Abstract :
[en] AIMS: The primary objective was to assess the occurrence rate of Medication-Related OsteoNecrosis of the Jaw (MRONJ) after dental extraction in patients treated with Anti-Resorptive Drugs (ARD) for OsteoPorosis (OP) or for oncological reasons. The secondary objective was to compare the extraction techniques regarding the occurrence of MRONJ. MATERIALS AND METHODS: A systematic search in PubMed/MEDLINE, EMBASE and LILACS databases was performed. Prospective studies considering human patients treated with ARD and providing information regarding the occurrence of MRONJ after dental extraction were selected. Meta-analysis for incidence of MRONJ at the patient level was performed. The effect of administration route and surgical technique on MRONJ was evaluated. RESULTS: The risk of MRONJ after dental extraction was significantly higher in patients treated with ARD for oncological reasons (3.2%) than in those treated with per os ARD for OP (0.15%) (p<0.0001). Dental extraction performed with adjusted extraction protocols decreased significantly MRONJ development. Potential risk indicators such as concomitant medications and pre-existing osteomyelitis were identified. CONCLUSION: The risk of MRONJ after dental extraction in patients treated with ARD exists, especially in patients treated for oncologic reasons. This risk tends to decrease with adjusted extraction protocols. This article is protected by copyright. All rights reserved.
Research center :
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Dentistry & oral medicine
Author, co-author :
GAUDIN, Elise ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
SEIDEL, Laurence  ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'Informations médico économiques (SIME)
Bacevic, Miljana ;  Université de Liège - ULiège > Form. doct. sc. dentaires
ROMPEN, Eric ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
LAMBERT, France ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
Language :
English
Title :
Occurrence and risk indicators of medication-related osteonecrosis of the jaw after dental extraction: a systematic review and meta-analysis.
Publication date :
12 September 2015
Journal title :
Journal of Clinical Periodontology
ISSN :
0303-6979
eISSN :
1600-051X
Publisher :
Wiley
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 November 2015

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