Article (Scientific journals)
Inhibitors of the FEZ-1 metallo-beta-lactamase
Lienard, B. M. R.; Horsfall, L. E.; Galleni, Moreno et al.
2007In Bioorganic and Medicinal Chemistry Letters, 17 (4), p. 964-968
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Keywords :
antibiotic; inhibition; metallo-beta-lactamases; structure-activity relationship
Abstract :
[en] Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K-i of 6.1 +/- 0.71 mu M against the FEZ-1 MBL but does not significantly inhibit the IMP-1, Bell, CphA or L1 MBLs. (c) 2006 Elsevier Ltd. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Chemistry
Author, co-author :
Lienard, B. M. R.
Horsfall, L. E.
Galleni, Moreno ;  Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Frère, Jean-Marie ;  Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Schofield, C. J.
Language :
English
Title :
Inhibitors of the FEZ-1 metallo-beta-lactamase
Publication date :
15 February 2007
Journal title :
Bioorganic and Medicinal Chemistry Letters
ISSN :
0960-894X
eISSN :
1464-3405
Publisher :
Pergamon-Elsevier Science Ltd, Oxford, United Kingdom
Volume :
17
Issue :
4
Pages :
964-968
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 November 2015

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