Reference : Risk adaptive treatment in Hodgkin's lympoma: reduction of radiation dose and irradiated...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Oncology
http://hdl.handle.net/2268/18833
Risk adaptive treatment in Hodgkin's lympoma: reduction of radiation dose and irradiated volume
English
Coucke, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Radiothérapie >]
Barthelemy, Nicole mailto [Centre Hospitalier Universitaire de Liège - CHU > > Radiothérapie >]
Hustinx, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2008
Belgian Journal of Medical Oncology [=BJMO]
2
2
85-97
Yes (verified by ORBi)
National
1784-7141
[en] Hodgkin’s lymphoma ; late effects ; radiotherapy
[fr] dose ; volume
[en] Treatment–related late complications on nontarget
normal tissues and appearance of secondary
malignancies are well known side-effects
induced by effective treatment regimens currently
used in the curative approach of early and
advanced Hodgkin’s lymphoma. Radiotherapy
(RT) and chemotherapy (CT) can lead to these
late complications. Efforts have been conducted
to reduce the morbidity and mortality related
to these treatments. In particular there has
been a progressive shift from radiotherapy used
as sole modality to chemotherapy as first line
followed by consolidation radiotherapy. As the
side-effects of radiotherapy are linked to dose,
volume and interaction with chemotherapy,
trials have been launched to assess the impact
of modifying the characteristics of the radiation
treatment. For early-stage Hodgkin’s lymphoma
radiotherapy cannot be avoided but dose and
volume can be reduced. In advanced Hodgkin’s
lymphoma omitting radiotherapy seems reasonable
only in case of complete response (CR). The
clinical trials allowing such a paradigm shift are
highlighted in this review.
Researchers ; Professionals
http://hdl.handle.net/2268/18833

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