Enhancement of concomitant immunity after radiation therapy and immunotherapy in a syngeneic murine tumour system

[en] Concomitant immunity was evaluated in vivo towards a chemically induced epidermoid carcinoma transplanted in a syngeneic situation. Radiation therapy reversed the declining phase of concomitant immunity associated with tumour progression. Radiation induced immune recovery was dose related and proved to be different from surgery effect.Corynebacterium parvum i.p. significantly improved concomitant immunity. Immunostimulation and irradiation act synergistically on host anti-tumour resistance.
[fr] L'immunité concomitante a été mesurée in vivo par rapport à un épithélioma épidermoïde chimio-induit transplanté en situation isogénique. La radiothérapie inverse la phase de déclin de l'immunité concomitante associée à la progression tumorale. La récupération immunitaire faisant suite à l'irradiation tumorale est dose dépendante et diffère de l'effet que peut avoir une exérèse chirurgicale. L'injection i.p. de Corynebacterium parvum améliore significativement l'immunité concomitante. L'immunostimulation et l'irradiation agissent de manière synergique sur la résistance anti-tumorale de l'hôte.

Research center :

Service universitaire de Radiothérapie ULiège Belgium

Disciplines :

Oncology

Author, co-author :

Deneufbourg, Jean-Marie ; Université de Liège Faculté de Médecine Chef de Travaux > Hôpital universitaire de Bavière Liège (Belgium) > Service de Radiothérapie (Pr. J. Closon)

Language :

English

Title :

Enhancement of concomitant immunity after radiation therapy and immunotherapy in a syngeneic murine tumour system

Alternative titles :

[fr] Augmentation de l'immunité concomitante après radiothérapie et immunothérapie dans un système tumoral murin syngénique

Publication date :

June 1982

Journal title :

Acta Radiologica. Oncology

ISSN :

0349-652X

Publisher :

Societies of Medical Radiology in Denmark Finland Norway and Sweden, Stockholm, Sweden

Volume :

Issue :

Pages :

345-348

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Fondation de Monsieur et Madame Braconier-Lamarche

Commentary :

Corynebacterium parvum was kindly supplied by Institut Mérieux LYON France

Available on ORBi :

since 19 November 2015

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Bibliography

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