Photodynamic therapy for cutaneous verrucous carcinoma

[en] Cutaneous verrucous carcinoma is a low-grade and well-differentiated variant of squamous cell carcinoma. This rare neoplasm follows a seemingly indolent progression and exhibits a low metastatic potential. Photodynamic therapy relies on the selective intratumoral cell accumulation and photoactivation of a photosensitizer, leading to the generation of phototoxic compounds responsible for necrosis and apoptosis of the target cells. An 82-year-old man presenting with a large long-standing verrucous carcinoma on the leg was treated successfully by 6 photodynamic therapy sessions administered at weekly intervals using methyl-aminolevulinate and 57-J/cm2 irradiations at 634-nm wavelength. The use of methyl-aminolevulinate–photodynamic therapy for treating cutaneous verrucous carcinoma had not been reported so far. It may represent a convenient therapeutic alternative in this setting.

Disciplines :

Dermatology

Author, co-author :

Nikkels, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > Dermatologie

Thirion, Laurence; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie

Language :

English

Title :

Photodynamic therapy for cutaneous verrucous carcinoma

Publication date :

2007

Journal title :

Journal of the American Academy of Dermatology

ISSN :

0190-9622

eISSN :

1097-6787

Publisher :

Mosby-Elsevier, New York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 November 2015

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Bibliography

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