ORBi: Nayjib Btissam - In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice

Reference : In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell respons...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/18769

Title :	In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice
Language :	English
Author, co-author :	Nayjib, Btissam [Université de Liège - ULg > Doct. sc. bioméd. & pharma. (Bologne)]
	Zeddou, Mustapha [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
	Drion, Pierre [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
	Boniver, Jacques [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
	Tasken, K. [University of Oslo > Biotechnology Centre of Oslo >]
	Rahmouni, Souad [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
	Moutschen, Michel [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Publication date :	2008
Journal title :	Open Immunol journal
Publisher :	Bentham
Volume :	1
Pages :	20-24
Audience :	International
ISSN :	1874-2262
e-ISSN :	1874-2262
Keywords :	[en] PKA Type I Inhibitor ; Retrovirus-Infected Mice ; T-Cell Responses
Abstract :	[en] Murine AIDS (MAIDS) is caused by infection with the murine leukemia retrovirus RadLV-Rs and is characterized by T-cell anergy and severe immunodeficiency with increased susceptibilty to several experimental opportunistic infections as observed in HIV infection. T cell anergy is associated with an increase of intracellular cAMP level, triggering a multistep pathway involving activation of PKA type I and resulting in inhibition of proximal TCR signaling. We have reviously demonstrated that blocking PKA type I using the selective inhibitor Rp-8-Br-cAMPS, restores T-cell function in vitro in MAIDS as well as in HIV infection. In the present report, we investigated the effect of parenteral administration of Rp-8-Br-cAMPS in mice with MAIDS. We show that the compound is not toxic and partially restores the ex vivo proliferative responses to anti-CD3 mAb, but that it has no effect on the lymphadenopathy and splenomegaly characterizing the MAIDS syndrome.
Research units :	Giga-Infection, Immunity and Inflammation
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/18769
DOI :	10.2174/1874226200801010020

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