Reference : The supercritical micronization of solid dispersions by Particles from Gas Saturated ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/18762
The supercritical micronization of solid dispersions by Particles from Gas Saturated Solutions using experimental design
English
Brion, Michaël mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Jaspart, Séverine [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Perrone, Leonardo [> >]
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Nov-2009
Journal of Supercritical Fluids
Elsevier Science
51
1
50-56
Yes (verified by ORBi)
International
0896-8446
Amsterdam
The Netherlands
[en] Experimental design ; Plackett-Burman ; central composite design ; supercritical carbon dioxide ; solid dispersion ; Particles from Gas Saturated Solutions
[en] The Particle from Gas Saturated Solutions process was successfully used to micronize solid
dispersions containing hydrophilic carriers and a new chemical entity, YNS3107. By means
of experimental design, the effects of several experimental parameters on micronization were
investigated. Within the chosen experimental conditions, the results showed that the autoclave
temperature, autoclave pressure, drug loading, flow rate of carbon dioxide and air pressure
were significant parameters. During the optimization step, the most relevant parameters of the
screening were optimized using a central composite design meanwhile other factors were kept
constant. Optimal conditions were used to produce microparticles with a volume weighted
mean diameter of 30.4 µm. The closeness between the measured and predicted response,
evaluated at 28.1 µm, demonstrated the validity of the statistical analyses. Finally, an
enhancement of the rate of dissolution of YNS3107 in the solid dispersion microparticles was
measured using USP II dissolution test apparatus.
Researchers ; Professionals
http://hdl.handle.net/2268/18762
10.1016/j.supflu.2009.06.021

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
J Supercritical fluids.pdfPublisher postprint542.67 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.