Article (Scientific journals)
Development of a new topical system: Drug-in-cyclodextrin-in-deformable liposome
Gillet, Aline; Grammenos, Angeliki; Compère, Philippe et al.
2009In International Journal of Pharmaceutics, 380 (1-2), p. 174-180
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Keywords :
Deformable liposome; Cyclodextrin; Betamethasone; Franz cells
Abstract :
[en] A new delivery system for cutaneous administration combining the advantages of cyclodextrin inclusion complexes and those of deformable liposomes was developed, leading to a new concept: drug-incyclodextrin-in-deformable liposomes. Deformable liposomes made of soybean phosphatidylcholine (PC) or dimyristoylphosphatidylcholine (DMPC) and sodium deoxycholate as edge activator were compared to classical non-deformable liposomes. Liposomes were prepared by the film evaporation method. Betamethasone, chosen as the model drug,was encapsulated in the aqueous cavity of liposomes by the use of cyclodextrins. Cyclodextrins allowan increase in the aqueous solubility of betamethasone and thus, the encapsulation efficiency in liposome vesicles. Liposome size, deformability and encapsulation efficiency were calculated. The best results were obtained with deformable liposomes made of PC in comparison with DMPC. The stability of PC vesicles was evaluated by measuring the leakage of encapsulated calcein on the one hand and the leakage of encapsulated betamethasone on the other hand. In vitro diffusion studies were carried out on Franz type diffusion cells through polycarbonate membranes. In comparison with non-deformable liposomes, these new vesicles showed improved encapsulation efficiency, good stability and higher in vitro diffusion percentages of encapsulated drug. They are therefore promising for future use in ex vivo and in vivo experiments.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Gillet, Aline ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Grammenos, Angeliki ;  Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Compère, Philippe ;  Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Département des sciences et gestion de l'environnement
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Language :
English
Title :
Development of a new topical system: Drug-in-cyclodextrin-in-deformable liposome
Publication date :
01 October 2009
Journal title :
International Journal of Pharmaceutics
ISSN :
0378-5173
eISSN :
1873-3476
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
380
Issue :
1-2
Pages :
174-180
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 August 2009

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