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Inclusion of Piroxicam into Beta-Cyclodextrin by Means of Supercritical Carbon Dioxide: Thermal, Spectroscopic and Physicochemical Studies
Van Hees, Thierry; Evrard, Brigitte; Piel, Géraldine et al.
2000In Journal de Pharmacie de Belgique, 55 (1, Jan-Feb), p. 30-1
 

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Abstract :
[en] The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. The solubility piroxicam in supercritical CO2 was determined. The influence of the temperature, the pressure and the time of exposure on the inclusion rate were studied and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 150 bar of CO2. This complex was characterised by Differential Scanning Calorimetry and Fourier Transform Infrared Spectrometry. Supercritical carbon dioxide may prove to be a novel useful complexation method of non-polar drugs into beta-cyclodextrin.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Van Hees, Thierry ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Inclusion of Piroxicam into Beta-Cyclodextrin by Means of Supercritical Carbon Dioxide: Thermal, Spectroscopic and Physicochemical Studies
Publication date :
2000
Audience :
International
Journal title :
Journal de Pharmacie de Belgique
ISSN :
0047-2166
Publisher :
Association Pharmaceutique Belge, Belgium
Volume :
55
Issue :
1, Jan-Feb
Pages :
30-1
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