Article (Scientific journals)
18F-FDG PET/CT in the Management of Aortitis.
Bruls, Samuel; Courtois, Audrey; Nusgens, Betty et al.
2015In Clinical Nuclear Medicine
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Abstract :
[en] BACKGROUND: Aortitis is a generic term defined as an inflammatory condition involving the aortic wall, of infectious or noninfectious origin. This inflammatory process may deteriorate the aortic wall, resulting in potentially life-threatening vascular complications. Therefore, it is important to establish a diagnosis as early as possible. PATIENTS AND METHODS: During a 4-year period, 428 consecutive patients referred to our department for aortic diseases underwent FDG PET/CT examinations. Among these, 18 patients (4.2%) were suspected to have aortitis. All of them had an initial positive FDG PET/CT uptake occurring in the aorta and major branches as evaluated by visual analysis of images and assessed with the final diagnosis of aortitis. During follow-up, after surgery and/or upon immunosuppressive treatment, each of these patients underwent a second PET/CT that was compared with the initial evaluation. In all cases, normalization of FDG uptake was correlated with clinical improvement. CONCLUSIONS: Our study aimed to illustrate the potential clinical value of functional monitoring with PET/CT in the management of aortitis. FDG PET/CT constitutes a valuable imaging modality to establish an early diagnosis, monitor disease progression and treatment, and evaluate vascular complication and relapse. We highlight the importance of an early detection of inflammatory large-vessel pathology, which may represent a major threat.
Disciplines :
Surgery
Author, co-author :
Bruls, Samuel   
Courtois, Audrey  ;  Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Nusgens, Betty ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Defraigne, Jean-Olivier ;  Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Delvenne, Philippe ;  Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Hustinx, Roland  ;  Université de Liège > Département des sciences cliniques > Médecine nucléaire
Moutschen, Michel  ;  Université de Liège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.
SAKALIHASAN, Natzi ;  Centre Hospitalier Universitaire de Liège - CHU > Service de Chirurgie cardio-vasculaire et thoracique
 These authors have contributed equally to this work.
Language :
English
Title :
18F-FDG PET/CT in the Management of Aortitis.
Publication date :
2015
Journal title :
Clinical Nuclear Medicine
ISSN :
0363-9762
eISSN :
1536-0229
Publisher :
Lippincott Williams & Wilkins, United States - Pennsylvania
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 October 2015

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