Article (Scientific journals)
Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss.
Maire, Micheline; Reichert, Carolin Franziska; Gabel, Virginie et al.
2015In Annals of Neurology, 78 (2), p. 235-47
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Keywords :
Adult; Arousal/genetics/physiology; Attention/physiology; Brain/physiopathology; Brain Stem/physiopathology; Circadian Rhythm/genetics/physiology; Female; Functional Neuroimaging; Gyrus Cinguli/physiopathology; Humans; Magnetic Resonance Imaging; Male; Neural Pathways/physiopathology; Period Circadian Proteins/genetics; Polymorphism, Genetic; Prefrontal Cortex/physiopathology; Psychomotor Performance/physiology; Reaction Time/genetics/physiology; Sleep Deprivation/genetics/physiopathology/psychology; Thalamus/physiopathology; Young Adult
Abstract :
[en] OBJECTIVE: Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored. METHODS: We assessed brain activity in young healthy adults during a vigilant attention task under high and low sleep pressure during night-time, coinciding with strongest circadian sleep drive. We examined sleep-loss-related attentional vulnerability by considering a PERIOD3 polymorphism presumably impacting on sleep homeostasis. RESULTS: Our results link higher sleep-loss-related attentional vulnerability to cortical and subcortical deactivation patterns during slow reaction times (i.e., suboptimal vigilant attention). Concomitantly, thalamic regions were progressively less recruited with time-on-task and functionally less connected to task-related and arousal-promoting brain regions in those volunteers showing higher attentional instability in their behavior. The data further suggest that the latter is linked to shifts into a task-inactive default-mode network in between task-relevant stimulus occurrence. INTERPRETATION: We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.
Disciplines :
Neurosciences & behavior
Author, co-author :
Maire, Micheline
Reichert, Carolin Franziska
Gabel, Virginie
Viola, Antoine U.
Phillips, Christophe  ;  Université de Liège > Centre de recherches du cyclotron
Krebs, Julia
Scheffler, Klaus
Klarhofer, Markus
Strobel, Werner
Cajochen, Christian
Schmidt, Christina  ;  Université de Liège > Département de Psychologie : cognition et comportement > Neuropsychologie
Language :
English
Title :
Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss.
Publication date :
2015
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Volume :
78
Issue :
2
Pages :
235-47
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2015 American Neurological Association.
Available on ORBi :
since 26 October 2015

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