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Preparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids
Alvarez, Covadonga; Van Hees, Thierry; Piel, Géraldine et al.
2001In STP Pharma Sciences, 11 (6), p. 439-442
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Keywords :
mebendazole; water-soluble polymers; organic acids; hydroxypropyl-beta-cyclodextrin
Abstract :
[en] Mebendazole (MBZ) is a carbamate derivative with an aminobenzimidazole structure. It possesses antihelminthic properties and is particularly insoluble in water. In order to increase its aqueous solubility, hydroxpropyl-beta-cyclodextrin (HP-beta-CD) was used in combination with water-soluble polymers (polyvinylpyrrolidone or hydroxypropymethyl cellulose) and different organic acids (citric or tartaric). Increased solubility was observed on heating the mixture. The effects of the time and temperature of the heating process on drug solubility and stability were investigated. The results clearly show that the best conditions for increasing solubility and limiting degradation of MBZ is to heat a combination of MBZ, HP-beta-CD (200 mM), tartaric or citric acid (50 mM) and HPMC (0.1% w/v) in a water-bath at 95degreesC for 60 min. This method increases solubility to about 680 mug/ml and limits degradation to 2.5%.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Alvarez, Covadonga
Van Hees, Thierry ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Liégeois, Jean-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Preparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids
Publication date :
2001
Journal title :
STP Pharma Sciences
ISSN :
1157-1489
Publisher :
Editions Sante, Paris, France
Volume :
11
Issue :
6
Pages :
439-442
Peer reviewed :
Peer reviewed
Available on ORBi :
since 13 August 2009

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