Article (Scientific journals)
One-step strategy for the synthesis of a derivatized cyclodextrin-based monolithic column.
Guo, Jialiang; Zhang, Qiaoxuan; Yao, Zhe et al.
2014In Journal of Separation Science, 37 (14), p. 1720-7
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Keywords :
Chromatography, High Pressure Liquid/instrumentation; Click Chemistry; Methacrylates/chemistry; beta-Cyclodextrins/chemical synthesis/chemistry; Derivatized beta-cyclodextrin; Monolithic columns
Abstract :
[en] Derivatized beta-cyclodextrin (beta-CD) functionalized monolithic columns were prepared by a "one-step" strategy using click chemistry. First, the intended derivatized beta-CD monomers were synthesized by a click reaction between propargyl methacrylate and mono-6-azido-beta-CD and then sulfonation or methylation was carried out. Finally, monolithic columns were prepared through a one-step in situ copolymerization of the derivatized beta-CD monomer and ethylene glycol dimethacrylate. The sulfated beta-CD-based monolith was successfully applied to the hydrophilic interaction liquid chromatography separation of nucleosides and small peptides, while the methylated beta-CD-functionalized monolith was useful for the separation of nonpolar compounds and drug enantiomers in capillary reversed-phase liquid chromatography. The structures of the monomers were characterized by Fourier transform infrared spectroscopy and mass spectrometry. The physicochemical properties and column performance of monoliths were evaluated by scanning electron microscopy and micro high performance liquid chromatography. This strategy has considerable prospects for the preparation of other derivatized CD-functionalized methacrylate monoliths.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Guo, Jialiang
Zhang, Qiaoxuan
Yao, Zhe
Zhao, Xianglong
Ran, Danni
Crommen, Jacques ;  Université de Liège > Département de pharmacie > Département de pharmacie
Jiang, Zhengjin
Language :
English
Title :
One-step strategy for the synthesis of a derivatized cyclodextrin-based monolithic column.
Publication date :
2014
Journal title :
Journal of Separation Science
ISSN :
1615-9306
eISSN :
1615-9314
Publisher :
Wiley, Weinheim, Germany
Volume :
37
Issue :
14
Pages :
1720-7
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available on ORBi :
since 24 October 2015

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