Article (Scientific journals)
Systematic characterization of oil-in-water emulsions for formulation design
Roland, Isabelle; Piel, Géraldine; Delattre, Luc et al.
2003In International Journal of Pharmaceutics, 263 (1-2), p. 85-94
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Keywords :
emulsion; characterization; stability; size
Abstract :
[en] Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out which tests should systematically be carried Out to assess efficiently the stability and the properties of ail emulsified preparation. Thus, formulation design requires at least the measurement of the droplet size, the determination of the zeta potential, a TurbiScan(R) analysis, the investigation of the stability under centrifugation and freeze/thaw cycles. If the emulsion contains an active substance, stability under storage at 4 degreesC and microscopic analysis are relevant. Quality Control Should be improved by measurements of viscosity and pH. (C) 2003 Elsevier B.V. All rights reserved.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Roland, Isabelle ;  Centre Hospitalier Universitaire de Liège - CHU > Pharmacie
Piel, Géraldine ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Language :
English
Title :
Systematic characterization of oil-in-water emulsions for formulation design
Publication date :
16 September 2003
Journal title :
International Journal of Pharmaceutics
ISSN :
0378-5173
eISSN :
1873-3476
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
263
Issue :
1-2
Pages :
85-94
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 August 2009

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