Reference : Systematic characterization of oil-in-water emulsions for formulation design
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/18717
Systematic characterization of oil-in-water emulsions for formulation design
English
Roland, Isabelle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pharmacie >]
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
16-Sep-2003
International Journal of Pharmaceutics
Elsevier Science Bv
263
1-2
85-94
Yes (verified by ORBi)
International
0378-5173
Amsterdam
[en] emulsion ; characterization ; stability ; size
[en] Oil-in-water emulsions varying in surfactant concentration and manufacturing process were prepared. About 10 experiments were performed to characterize them. The goal of this research was to find Out which tests should systematically be carried Out to assess efficiently the stability and the properties of ail emulsified preparation. Thus, formulation design requires at least the measurement of the droplet size, the determination of the zeta potential, a TurbiScan(R) analysis, the investigation of the stability under centrifugation and freeze/thaw cycles. If the emulsion contains an active substance, stability under storage at 4 degreesC and microscopic analysis are relevant. Quality Control Should be improved by measurements of viscosity and pH. (C) 2003 Elsevier B.V. All rights reserved.
Researchers ; Professionals
http://hdl.handle.net/2268/18717

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
article.pdfPublisher postprint178.03 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.