hepatitis C virus; genotype 4; treatment; epidemiology; genotype; drug users; immigration; treatment eligibility; subtypes
Abstract :
[en] Background Considered uncommon in western countries some years ago, hepatitis C virus of genotype 4 is now spreading in some areas of Europe. This is assumed to be due to immigration from a region of high prevalence for this genotype and to propagation among drug users. In the south of Belgium, genotype 4 currently accounts for 10% of hepatitis C virus patients and its prevalence is increasing with time. Objective To better define the genotype 4 carriers' characteristics. Methods In a database comprising 1726 viraemic hepatitis C virus patients, the files of 85 genotype 4 carriers were reviewed. Results Beside the African (58%) and European drug user (15%) subgroups classically described, a third subgroup consisting of European nondrug users (26%) was identified as peculiar: these patients were older, had been mostly contaminated sporadically, presented a great diversity of subtypes, and were mainly of Italian origin. In this subgroup, contamination was supposed to be ancient, having occurred probably in Italy before immigration into Belgium. By contrast, European drug users were infected with only two subtypes (4c/4d and 4), an observation in favour of recent spread. Africans had a great diversity of subtypes, were young, and were mostly contaminated sporadically in their home countries. Despite their epidemiological differences, the clinical management, and in particular the rates of eligibility for treatment, were similar for these three groups. Conclusions Three different patterns of genotype 4 carriers were observed, corresponding to three different spreading profiles. They did not induce, however, different clinical management.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Delwaide, Jean ; Université de Liège - ULiège > Gastro-Entérologie-Hépatologie
Reenaers, Catherine ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Gerard, Christiane ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Vaira, Dolorès ; Centre Hospitalier Universitaire de Liège - CHU > Immuno-hématologie
Bastens, B.
Serwir, Brigitte ; Centre Hospitalier Universitaire de Liège - CHU > Administration des patients - Encodage
Bekhti, A.
Bataille, Christian ; Université de Liège - ULiège > Département des sciences cliniques
Wain, E.
De Leeuw, P.
Daenen, Guy ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Mesureur, Thierry ; Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Sente, J. M.
Belaiche, Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
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