Reference : HCV genotype 4 in Belgium: three distinct patterns among patients from European and A...
Scientific journals : Article
Human health sciences : Gastroenterology & hepatology
http://hdl.handle.net/2268/18708
HCV genotype 4 in Belgium: three distinct patterns among patients from European and African origin
English
Delwaide, Jean mailto [Université de Liège - ULg > > Gastro-Entérologie-Hépatologie >]
Reenaers, Catherine [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
Gerard, Christiane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Vaira, Dolorès mailto [Centre Hospitalier Universitaire de Liège - CHU > > Immuno-hématologie >]
Bastens, B. [> > > >]
Serwir, Brigitte mailto [Centre Hospitalier Universitaire de Liège - CHU > > Administration des patients - Encodage >]
Bekhti, A. [> > > >]
Bataille, Christian [Université de Liège - ULg > > Département des sciences cliniques >]
Wain, E. [> > > >]
De Leeuw, P. [> > > >]
Daenen, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Mesureur, Thierry [Centre Hospitalier Universitaire de Liège - CHU > > Gastro-Entérologie-Hépatologie >]
Sente, J. M. [> > > >]
Belaiche, Jacques mailto [Université de Liège - ULg > Département des sciences cliniques > Hépato-gastroentérologie]
Jul-2006
European Journal of Gastroenterology & Hepatology
Lippincott Williams & Wilkins
18
7
707-712
Yes (verified by ORBi)
International
0954-691X
Philadelphia
[en] hepatitis C virus ; genotype 4 ; treatment ; epidemiology ; genotype ; drug users ; immigration ; treatment eligibility ; subtypes
[en] Background Considered uncommon in western countries some years ago, hepatitis C virus of genotype 4 is now spreading in some areas of Europe. This is assumed to be due to immigration from a region of high prevalence for this genotype and to propagation among drug users. In the south of Belgium, genotype 4 currently accounts for 10% of hepatitis C virus patients and its prevalence is increasing with time. Objective To better define the genotype 4 carriers' characteristics. Methods In a database comprising 1726 viraemic hepatitis C virus patients, the files of 85 genotype 4 carriers were reviewed. Results Beside the African (58%) and European drug user (15%) subgroups classically described, a third subgroup consisting of European nondrug users (26%) was identified as peculiar: these patients were older, had been mostly contaminated sporadically, presented a great diversity of subtypes, and were mainly of Italian origin. In this subgroup, contamination was supposed to be ancient, having occurred probably in Italy before immigration into Belgium. By contrast, European drug users were infected with only two subtypes (4c/4d and 4), an observation in favour of recent spread. Africans had a great diversity of subtypes, were young, and were mostly contaminated sporadically in their home countries. Despite their epidemiological differences, the clinical management, and in particular the rates of eligibility for treatment, were similar for these three groups. Conclusions Three different patterns of genotype 4 carriers were observed, corresponding to three different spreading profiles. They did not induce, however, different clinical management.
http://hdl.handle.net/2268/18708

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