Poster (Scientific congresses and symposiums)
Myoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells.
Fahmy, Karim
20156ième congrès de la Société Francaçais de l'Angiogenèse
 

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Keywords :
myoferlin; angiogenesis; VEGF-A
Abstract :
[en] In this poster, our laboratory showed the importance of myoferlin, a biomarker of pancreas cancer, in the controle of VEGF-A mediated angiogenesis. Our laboratory showed that silencing myoferlin in pancreas cancer cells, BxPC-3, provoques a decrease in cell prolifération in vitro and a decrease in tumor volumes in animal model. Myoferlin silencing also provokes a decrease in VEGF-A secretion in the conditioned medium and that decrease was abserved in the animal model as a decrease in microvessels dencity. It appeared that this decrease in secretion is due to a a blockage in the exocytosis. Our data also showed a significate correlation between myoferlin expression and microvessels density in patients section.
Disciplines :
Oncology
Author, co-author :
Fahmy, Karim ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Language :
English
Title :
Myoferlin: an indispensable component in VEGFA secretion by pancreas cancer cells.
Publication date :
24 September 2015
Event name :
6ième congrès de la Société Francaçais de l'Angiogenèse
Event organizer :
Collège de France
Event place :
Paris, France
Event date :
du 24 September 2015 au 25 Semptembre 2015
Audience :
International
Available on ORBi :
since 20 October 2015

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