Article (Scientific journals)
Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells.
LANCELLOTTI, Patrizio; NCHIMI LONGANG, Alain; Delierneux, Céline et al.
2015In Circulation: Cardiovascular Imaging, 8 (9)
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Keywords :
DNA damage; blood cells; cell death; flow cytometry; lymphocytes
Abstract :
[en] BACKGROUND: Cardiac magnetic resonance (CMR) is increasingly used for the diagnosis and management of cardiac diseases. Recent studies have reported immediate post-CMR DNA double-strand breaks in T lymphocytes. We sought to evaluate CMR-induced DNA damage in lymphocytes, alterations of blood cells, and their temporal persistence. METHODS AND RESULTS: In 20 prospectively enrolled healthy men (31.4+/-7.9 years), blood was drawn before and after (1-2 hours, 2 days, 1 month, and 1 year) unenhanced 1.5T CMR. Blood cell counts, cell death, and activation status of lymphocytes, monocytes, neutrophils, and platelets were evaluated. The first 2-hour post-CMR were characterized by a small increase of lymphocyte B and neutrophil counts and a transient drop of total lymphocytes because of a decrease in natural killer cells. Among blood cells, only neutrophils and monocytes displayed slight and transient activation. DNA double-strand breaks in lymphocytes were quantified through flow cytometric analysis of H2AX phosphorylation (gamma-H2AX). gamma-H2AX intensity in T lymphocytes did not change early after CMR but increased significantly at day 2 </=1 month before returning to baseline levels of 1-year post-CMR. CONCLUSIONS: Unenhanced CMR is associated with minor but significant immediate blood cell alterations or activations figuring inflammatory response, as well as DNA damage in T lymphocytes observed from day 2 until the first month but disappearing at 1-year follow-up. Although further studies are required to definitely state whether CMR can be used safely, our findings already call for caution when it comes to repeat this examination within a month.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
LANCELLOTTI, Patrizio  ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
NCHIMI LONGANG, Alain ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Delierneux, Céline ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Hego, Alexandre ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Gosset, Christiane ;  Université de Liège > Département des sciences de la santé publique > Santé publique : aspects généraux
Gothot, André ;  Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la coagulation et de l'hémostase
TSHIBANDA, Luaba ;  Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Oury, Cécile  ;  Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine
Language :
English
Title :
Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells.
Publication date :
2015
Journal title :
Circulation: Cardiovascular Imaging
ISSN :
1941-9651
eISSN :
1942-0080
Publisher :
Lippincott Williams & Wilkins, United States
Volume :
8
Issue :
9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2015 American Heart Association, Inc.
Available on ORBi :
since 18 October 2015

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