Article (Scientific journals)
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Janssen, Lauriane; Dupont, Laura; Bekhouche, Mourad et al.
2016In Angiogenesis, 19, p. 53-65
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Keywords :
ADAMTS; Angiogenesis; Collagen; Development; Lymphangiogenesis; Placenta
Abstract :
[en] The only documented activity of a subclass of ADAMTS proteases comprising ADAMTS2, 3 and 14 is the cleavage of the aminopropeptide of fibrillar procollagens. A limited number of in vitro studies suggested that ADAMTS3 is mainly responsible for procollagen II processing in cartilage. Here, we created an ADAMTS3 knockout mouse (Adamts3-/-) model to determine in vivo the actual functions of ADAMTS3. Heterozygous Adamts3+/- mice were viable and fertile, but their intercrosses demonstrated lethality of Adamts3-/- embryos after 15 days of gestation. Procollagens I, II and III processing was unaffected in these embryos. However, a massive lymphedema caused by the lack of lymphatics development, an abnormal blood vessel structure in the placenta and a progressive liver destruction were observed. These phenotypes are most probably linked to dysregulation of the VEGF-C pathways. This study is the first demonstration that an aminoprocollagen peptidase is crucial for developmental processes independently of its primary role in collagen biology and has physiological functions potentially involved in several human diseases related to angiogenesis and lymphangiogenesis.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Janssen, Lauriane 
Dupont, Laura  
Bekhouche, Mourad ;  Université de Liège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Noël, Agnès ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Leduc, Cédric ;  Université de Liège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Voz, Marianne  ;  Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Peers, Bernard ;  Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Cataldo, Didier  ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Apte, Suneel S.
Dubail, Johanne 
Colige, Alain  ;  Université de Liège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
 These authors have contributed equally to this work.
Language :
English
Title :
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Publication date :
2016
Journal title :
Angiogenesis
ISSN :
0969-6970
eISSN :
1573-7209
Publisher :
Kluwer Academic Publishers, Dordrecht, Netherlands
Volume :
19
Pages :
53-65
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 October 2015

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