Reference : Study of the interaction between cyclodextrins and liposome membranes: effect on the ...
Scientific congresses and symposiums : Paper published in a journal
Human health sciences : Pharmacy, pharmacology & toxicology
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/18664
Study of the interaction between cyclodextrins and liposome membranes: effect on the permeability of liposomes
English
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Piette, Marie mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Barillaro, Valery [> > > >]
Castagne, Delphine [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Apr-2007
Journal of Inclusion Phenomena and Macrocyclic Chemistry
Springer
57
1-4
309-311
Yes (verified by ORBi)
International
0923-0750
Dordrecht
[en] liposome ; cyclodextrin ; cholesterol ; calcein ; membrane permeability
[en] We wanted to compare and understand the effect of the most currently used cyclodextrins on a model membrane. We studied the influence of most currently used cyclodextrins on the release of a fluorescent marker encapsulated in the inner cavity of SUV liposomes. It was shown that the observed effect on calcein release can be directly related to the affinity of cyclodextrins for both lipid components of liposomes, cholesterol and phosphatidylcholine. From this relationship, we were able to determine, for each cyclodextrin, a theoretical concentration giving rise to 50% or 100% calcein release. This theoretical concentration was confirmed experimentally.
Researchers ; Professionals
http://hdl.handle.net/2268/18664

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