Thin-layer chromatography; Column liquid chromatography; Dexamethasone related compounds; Mass spectrometry; Illicit drug formulations
Abstract :
[en] A methodology for the analysis of dexamethasone and related compounds is proposed. Nine corticoids (corticosteroids) have been separated by TLC and by normalphase
HPLC. The optimization of the HPLC separation is performed on a diol column and with a n-hexane/isopropanol (80:20) mobile phase. Mass spectrometry is used to elucidate the nature of the compounds isolated from illicit drug formulations and to confirm the structure of synthesised derivatives from the parent dexamethasone.
Disciplines :
Chemistry
Author, co-author :
Gaignage, P.
Lognay, Georges ; Université de Liège - ULiège > Gembloux Agro-Bio Tech
Marlier, M.
Severin, M.
Dreze, P.
Language :
English
Title :
Applications Of Chromatographic And Spectrometric Techniques To The Study Of Dexamethasone Related-Compounds
