Article (Scientific journals)
Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury.
Rowart, Pascal; ERPICUM, Pauline; Detry, Olivier et al.
2015In Journal of Immunology Research, 602597
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Abstract :
[en] Ischemia/reperfusion injury (IRI) represents a worldwide public health issue of increasing incidence. IRI may virtually affect all organs and tissues and is associated with significant morbidity and mortality. Particularly, the duration of blood supply deprivation has been recognized as a critical factor in stroke, hemorrhagic shock, or myocardial infarction, as well as in solid organ transplantation (SOT). Pathophysiologically, IRI causes multiple cellular and tissular metabolic and architectural changes. Furthermore, the reperfusion of ischemic tissues induces both local and systemic inflammation. In the particular field of SOT, IRI is an unavoidable event, which conditions both short- and long-term outcomes of graft function and survival. Clinically, the treatment of patients with IRI mostly relies on supportive maneuvers since no specific target-oriented therapy has been validated thus far. In the present review, we summarize the current literature on mesenchymal stromal cells (MSC) and their potential use as cell therapy in IRI. MSC have demonstrated immunomodulatory, anti-inflammatory, and tissue repair properties in rodent studies and in preliminary clinical trials, which may open novel avenues in the management of IRI and SOT.
Disciplines :
Urology & nephrology
Author, co-author :
Rowart, Pascal ;  Université de Liège > Département des sciences cliniques > Néphrologie
ERPICUM, Pauline 
Detry, Olivier  
WEEKERS, Laurent  
Grégoire, Céline  ;  Université de Liège > GIGA-R : Hématologie
LECHANTEUR, Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Laboratoire de thérapie cellulaire et génique (LTCG)
BRIQUET, Alexandra 
Beguin, Yves  ;  Université de Liège > GIGA-R : Hématologie
Krzesinski, Jean-Marie ;  Université de Liège > Département des sciences cliniques > Néphrologie
Jouret, François  ;  Université de Liège > Département des sciences cliniques > Néphrologie
Language :
English
Title :
Mesenchymal Stromal Cell Therapy in Ischemia/Reperfusion Injury.
Publication date :
2015
Journal title :
Journal of Immunology Research
ISSN :
2314-8861
eISSN :
2314-7156
Publisher :
Hindawi, London, United Kingdom
Volume :
602597
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 September 2015

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