Reference : In Vitro Comparison of the Antimycotic Activity of a Miconazole-Hp-Beta-Cyclodextrin Sol...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/18562
In Vitro Comparison of the Antimycotic Activity of a Miconazole-Hp-Beta-Cyclodextrin Solution with a Miconazole Surfactant Solution
English
Piel, Géraldine mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique et magistrale >]
Hayette, Marie-Pierre mailto [Université de Liège - ULg > > Microbiologie médicale >]
Pavoni, Ermanno [> > > >]
Evrard, Brigitte mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie galénique >]
Van Hees, Thierry mailto [Université de Liège - ULg > Département de pharmacie > Pharmacie clinique]
Henry de Hassonville, Sandrine [> >]
De Mol, Patrick mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale]
Delattre, Luc mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Jul-2001
Journal of Antimicrobial Chemotherapy
48
1
83-7
Yes (verified by ORBi)
International
0305-7453
[en] The antimycotic activity of a new parenteral solution containing miconazole was compared with that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the Belgian market, probably because of toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing miconazole (10 mg/mL) (like the marketed solution), in combination with hydroxypropyl-beta-cyclodextrin and lactic acid. The MICs of these two solutions were determined by a broth microdilution method (based on NCCLS guidelines) for 67 yeasts and 50 filamentous fungi isolates. This study shows that the MICs obtained with these two solutions are not significantly different.
Researchers ; Professionals
http://hdl.handle.net/2268/18562

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