Article (Scientific journals)
Politeal vein blood sampling and the post-mortem redistribution of diazepam, methadone and morphine
Lemaire, Eric; Schmidt, Carl; DENOOZ, Raphael et al.
2016In Journal of Forensic Sciences
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Keywords :
forensic science; forensic toxicology; postmortem redistribution; popliteal blood; diazepam; methadone; morphine
Abstract :
[en] Postmortem redistribution (PMR) refers to the site- and time-related blood drug concentration variations after death. We compared central blood (cardiac and subclavian) with peripheral blood (femoral and popliteal) concentrations of diazepam, methadone, and morphine. To our knowledge, popliteal blood has never been compared with other sites. Intracardiac blood (ICB), subclavian blood (SB), femoral blood (FB), and popliteal blood (PB) were sampled in 30 cases. To assess PMR, mean concentrations and ratios were compared. Influence of postmortem interval on mean ratios was also assessed. Results show that popliteal mean concentrations were lower than those for other sites for all three drugs, even lower than femoral blood; mean ratios suggested that the popliteal site was less subject to PMR, and estimated postmortem interval did not influence ratios except for diazepam and methadone FB/PB. In conclusion, our study is the first to explore the popliteal site and suggests that popliteal blood is less prone to postmortem redistribution.
Disciplines :
Pharmacy, pharmacology & toxicology
Forensic medicine
Author, co-author :
Lemaire, Eric ;  Université de Liège > Département des sciences de la santé publique > Médecine légale - Criminalistique
Schmidt, Carl
DENOOZ, Raphael ;  Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique
Charlier, Corinne  ;  Université de Liège > Département de pharmacie > Chimie toxicologique
Boxho, Philippe ;  Université de Liège > Département des sciences de la santé publique > Médecine légale - Criminalistique
Language :
English
Title :
Politeal vein blood sampling and the post-mortem redistribution of diazepam, methadone and morphine
Publication date :
2016
Journal title :
Journal of Forensic Sciences
ISSN :
0022-1198
eISSN :
1556-4029
Publisher :
ASTM International, Philadelphia, United States - Pennsylvania
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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