No full text
Article (Scientific journals)
Stable Inhibition of Nuclear Factor Kappab in Cancer Cells Does Not Increase Sensitivity to Cytotoxic Drugs
Bentires-Alj, M.; Hellin, Anne-Cécile; Ameyar, M. et al.
1999In Cancer Research, 59 (4), p. 811-5
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] Several reports indicated that nuclear factor kappaB (NF-kappaB) activation by cytokines, cytotoxic drugs, or ionizing radiation protects cells against apoptosis. Therefore, we investigated the consequence of NF-kappaB inhibition on the efficiency of antineoplastic agents. HPB, HCT116, MCF7, and OVCAR-3 cells stably expressing a dominant negative IkappaBalpha inhibitor showed a decreased NF-kappaB activation following treatment with tumor necrosis factor a and various chemotherapeutic agents. However, there was no difference in survival between parental cells and cells expressing mutated IkappaBalpha. These studies suggest that, at least in these cell lines, stable NF-kappaB inhibition did not modify the response to cytotoxic drugs.
Disciplines :
Oncology
Author, co-author :
Bentires-Alj, M.
Hellin, Anne-Cécile 
Ameyar, M.
Chouaib, S.
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Language :
English
Title :
Stable Inhibition of Nuclear Factor Kappab in Cancer Cells Does Not Increase Sensitivity to Cytotoxic Drugs
Publication date :
10 February 1999
Journal title :
Cancer Research
ISSN :
0008-5472
eISSN :
1538-7445
Publisher :
American Association for Cancer Research, United States - Maryland
Volume :
59
Issue :
4
Pages :
811-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 August 2009

Statistics


Number of views
38 (6 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
97
Scopus citations®
without self-citations
81

Bibliography


Similar publications



Contact ORBi