Reference : Inverse Modulation of Il-10 and Il-12 in the Blood of Women with Preneoplastic Lesions o...
Scientific journals : Article
Human health sciences : Oncology
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/18492
Inverse Modulation of Il-10 and Il-12 in the Blood of Women with Preneoplastic Lesions of the Uterine Cervix
English
Jacobs, Nathalie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Giannini, Sandra L [> > > >]
Doyen, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Baptista, A. [> > > >]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Delvenne, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Jan-1998
Clinical & Experimental Immunology
111
1
219-24
Yes (verified by ORBi)
International
0009-9104
[en] Cytokines ; uterine cervix ; Human papillomavirus
[en] It has been postulated that an impaired immune response may contribute to the progression of human papillomavirus (HPV)-associated preneoplastic lesions. Based on this hypothesis, we evaluated the cytokine production in the blood of patients with squamous intraepithelial lesions (SIL) of the uterine cervix. The levels of type-1 (interferon-gamma (IFN-gamma) and IL-12) and type-2(IL-4 and IL-10) cytokines were measured in whole blood culture supernatants of patients with low- and high-grade SIL and control women. There was no difference in IL-4 and IFN-gamma levels between patients with SIL and the control group. In contrast, the ratio of IL-12/IL-10 levels was significantly lower in patients with SIL compared with the control group. A lower IL-12/IL-10 ratio in women with SIL was also observed when peripheral blood mononuclear cell (PBMC) culture supernatants and plasma samples were analysed. In patients, neither the lower expression of the CD3epsilon chain nor the higher frequency of HLA-DRB1*1501 expression could be correlated with abnormal cytokine production. These results suggest that a part of the cytokine network, namely IL-10 and IL-12, is perturbed in patients with SIL. A better knowledge of the role of these cytokines in regulating the growth of HPV-associated SIL might have practical implications for the development of vaccines or immunomodulatory strategies in the treatment of cervical cancers.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; centre anticancéreux au près d l'université de Liège ; Centre de recherche interuniversitaire en vaccinologie (région Wallonne et GSK)
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/18492

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