|Reference : Nuclear Factor-Kappa B, Cancer, and Apoptosis|
|Scientific journals : Article|
|Human health sciences : Oncology|
|Nuclear Factor-Kappa B, Cancer, and Apoptosis|
|Bours, Vincent [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine]|
|Bentires-Alj, M. [> > > >]|
|Hellin, A. C. [> > > >]|
|Viatour, Patrick [Université de Liège - ULg > > Chimie médicale >]|
|Robe, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Génétique générale et humaine >]|
|Delhalle, S. [> > > >]|
|Benoit, V. [> > > >]|
|Merville, Marie-Paule [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]|
|[en] The role of nuclear factor (NF)-kappa B in the regulation of apoptosis in normal and cancer cells has been extensively studied in recent years. Constitutive NF-kappa B activity in B lymphocytes as well as in Hodgkin's disease and breast cancer cells protects these cells against apoptosis. It has also been reported that NF-kappa B activation by tumor necrosis factor (TNF)-alpha, chemotherapeutic drugs, or ionizing radiations can protect several cell types against apoptosis, suggesting that NF-kappa B could participate in resistance to cancer treatment. These observations were explained by the regulation of antiapoptotic gene expression by NF-kappa B. However, in our experience, inhibition of NF-kappa B activity in several cancer cell lines has a very variable effect on cell mortality, depending on the cell type, the stimulus, and the level of NF-kappa B inhibition. Moreover, in some experimental systems, NF-kappa B activation is required for the onset of apoptosis. Therefore, it is likely that the NF-kappa B antiapoptotic role in response to chemotherapy is cell type- and signal-dependent and that the level of NF-kappa B inhibition is important. These issues will have to be carefully investigated before considering NF-kappa B as a target for genetic or pharmacological anticancer therapies.|
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