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Roles of Nuclear Factor-Kappab, P53, and P21/Waf1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
Hellin, Anne-Cécile; Bentires-Alj, M.; Verlaet, Myriam et al.
2000In Journal of Pharmacology and Experimental Therapeutics, 295 (3), p. 870-8
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Abstract :
[en] Daunomycin is a potent inducer of p53 and NF-kappaB transcription factors. It is also able to increase the amount of the p21 cyclin-dependent kinase inhibitor. The human p21 promoter harbors p53-responsive elements and an NF-kappaB binding site.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Hellin, Anne-Cécile 
Bentires-Alj, M.
Verlaet, Myriam ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine)
Benoit, V.
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Génétique générale et humaine
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Roles of Nuclear Factor-Kappab, P53, and P21/Waf1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis
Publication date :
December 2000
Journal title :
Journal of Pharmacology and Experimental Therapeutics
ISSN :
0022-3565
eISSN :
1521-0103
Publisher :
American Society for Pharmacology and Experimental Therapeutics, United States - Maryland
Volume :
295
Issue :
3
Pages :
870-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 August 2009

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