Reference : New insights into short-chain prenyltransferases: structural features, evolutionary hist...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/18468
New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition.
English
Vandermoten, Sophie mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Haubruge, Eric mailto [Université de Liège - ULg > Gembloux Agro-Bio Tech > Gembloux Agro-Bio Tech >]
Cusson, M. [> > > >]
2009
Cellular and Molecular Life Sciences : CMLS
Springer Science & Business Media B.V.
66
3685–3695
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] Isoprenoid ; Prenyltransferase ; Short-chain isoprenyl diphosphate synthase ; Geranyl diphosphate synthase ; Farnesyl diphosphate synthase ; Geranylgeranyl diphosphate synthase
[en] Isoprenoids form an extensive group of natural products involved in a number of important biological processes. Their biosynthesis proceeds through sequential 1'-4 condensations of isopentenyl diphosphate (C(5)) with an allylic acceptor, the first of which is dimethylallyl diphosphate (C(5)). The reactions leading to the production of geranyl diphosphate (C(10)), farnesyl diphosphate (C(15)) and geranylgeranyl diphosphate (C(20)), which are the precursors of mono-, sesqui- and diterpenes, respectively, are catalyzed by a group of highly conserved enzymes known as short-chain isoprenyl diphosphate synthases, or prenyltransferases. In recent years, the sequences of many new prenyltransferases have become available, including those of several plant and animal geranyl diphosphate synthases, revealing novel mechanisms of product chain-length selectivity and an intricate evolutionary path from a putative common ancestor. Finally, there is considerable interest in designing inhibitors specific to short-chain prenyltransferases, for the purpose of developing new drugs or pesticides that target the isoprenoid biosynthetic pathway.
http://hdl.handle.net/2268/18468
10.1007/s00018-009-0100-9

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Vandermoten et al.pdfI have transferred the copyright for this publication to the publisher Author preprint158.2 kBView/Open
Restricted access
fulltext.pdfI have transferred the copyright for this publication to the publisherPublisher postprint377.04 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.