Reference : Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclero...
Scientific congresses and symposiums : Poster
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/18450
Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclerosis in apoe–deficient (apo e-/-) mice
English
Cherdon, Céline mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Rolin, Stéphanie mailto [> >]
Hanson, Julien mailto [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
Drion, Pierre mailto [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
Dogné, Jean-Michel mailto [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
11-Oct-2007
Yes
International
Treizième forum des sciences pharamceutiques
11-12 octobre 2007
Spa
Belgique
[en] thromboxane receptor antagonist ; (apo e-/-) mice ; atherosclerosis
[en] To test the efficacy of BM-573 in atherogenesis, the effect of 10 weeks of treatment with BM573 (10 mg/l) on early aortic atherosclerotic lesions of apo E deficient mice was assessed. These mice were fed with chow diet, with spontaneous increase of total plasma cholesterol and triglycerides. In this experiment, while BM-573 did not affect body weight, it significantly decreases early atherogenesis lesions confirmed by macroscopic, microscopic and biochemical analysis. These results confirm that selective antagonism of TP receptor is effective in reducing atherosclerotic lesion in apo E deficient mice. Consequently, BM-573 could be a potential drug for prevention of atherosclerosis
Researchers ; Professionals
http://hdl.handle.net/2268/18450

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