ORBi: Cherdon Céline - Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclerosis in apoe

Reference : Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclero...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/18450

Title :	Bm-573, an original thromboxane receptor antagonist, reduces development of atherosclerosis in apoe–deficient (apo e-/-) mice
Language :	English
Author, co-author :	Cherdon, Céline [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
	Rolin, Stéphanie [> >]
	Hanson, Julien [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
	Drion, Pierre [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
	de Leval, Laurence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
	Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
	Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
Publication date :	11-Oct-2007
Peer reviewed :	Yes
Audience :	International
Event name :	Treizième forum des sciences pharamceutiques
Event date :	11-12 octobre 2007
Event place (city) :	Spa
Event country :	Belgique
Keywords :	[en] thromboxane receptor antagonist ; (apo e-/-) mice ; atherosclerosis
Abstract :	[en] To test the efficacy of BM-573 in atherogenesis, the effect of 10 weeks of treatment with BM573 (10 mg/l) on early aortic atherosclerotic lesions of apo E deficient mice was assessed. These mice were fed with chow diet, with spontaneous increase of total plasma cholesterol and triglycerides. In this experiment, while BM-573 did not affect body weight, it significantly decreases early atherogenesis lesions confirmed by macroscopic, microscopic and biochemical analysis. These results confirm that selective antagonism of TP receptor is effective in reducing atherosclerotic lesion in apo E deficient mice. Consequently, BM-573 could be a potential drug for prevention of atherosclerosis
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/18450

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