ORBi: Cherdon Céline - The use of an apoE–deficient (apoE-/-) mice model to characterize the therapeutic benefits of original thromboxane modulators

Reference : The use of an apoE–deficient (apoE-/-) mice model to characterize the therapeutic benefi...


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/18449

Title :	The use of an apoE–deficient (apoE-/-) mice model to characterize the therapeutic benefits of original thromboxane modulators
Language :	English
Author, co-author :	Cherdon, Céline [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
	Rolin, stephanie [ > > ]
	Hanson, Julien [Université de Liège - ULg > Département de pharmacie > Chimie pharmaceutique >]
	Duwez, Luc [Université de Liège - ULg > > Services généraux de l'Université >]
	Drion, Pierre [Université de Liège - ULg > Services généraux (Faculté de médecine vétérinaire) > Méth. expér. des anim. de labo et éthique en expér. animale >]
	Pincemail, Joël [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	de Leval, Laurence [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
	Defraigne, Jean-Olivier [Université de Liège - ULg > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique >]
	Dogné, Jean-Michel [Université de Liège - ULg > Département de pharmacie > Département de pharmacie >]
Publication date :	17-May-2006
Audience :	International
Event name :	Bioforum 2006, Liège, Belgique.
Event organizer :	Bioforum
Event place (city) :	Liège
Event country :	Belgium
Keywords :	[en] Apo E deficient mice ; thromboxane modulators ; atherosclerosis
Abstract :	[en] The aim of our study was to use an apoE–deficient mouse model to test drugs acting as thromboxane A2 antagonist. Presented here is the “en face” method 6 which allows the evaluation of atherosclerosis lesions development in wild type and APO E-/- mice. This method involves pinning out the aorta and quantifying lesion area as a percentage of total surface area. The use of this mice model offers a unique opportunity to characterize the therapeutic benefits of pharmacologicals agents designed in our laboratory of which antioxidants and thromboxane modulators. The pharmacological characterization of BM-573 as potential antiatherosclerotic agent will also be discussed
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/18449

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