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Cerebral FDG uptake changes with supraorbital transcutaneous electrical stimulation for episodic migraine prevention
D'Ostilio, Kevin; Thibaut, Aurore; Laureys, Steven et al.
2015International Headache Congress
 

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Keywords :
migraine; neurostimulation; neuroimaging
Abstract :
[en] Background: A recent multicentre RCT has shown that supraorbital transcutaneous stimulation (STS) targeting branches of the ophtalmic nerve with the Cefaly® device is effective as a preventive therapy for migraine (Schoenen et al., Neurology 2013). However, the mechanisms of action in the central nervous system remain unknown. Here, we conducted voxel-based analyses of [18]FDG-PET to evaluate metabolic changes immediately after the first STS session and after 3 months of treatment in patients with migraine. Methods: Twenty-eight subjects participated in the experiment: 14 patients with episodic migraine (ICHD3 beta criteria) and 14 age-matched controls. Healthy volunteers underwent only one [18]FDG-PET scan whereas patients were scanned at baseline, directly after a first session of STS and after 3 months of daily treatment. Results: Compliant patients showed a significant decrease in the number of attacks (p = 0.03). When compared to controls, patients (n = 14) at baseline were hypometabolic in the fronto-temporal regions (p < 0.001), especially in the orbitofrontal (OFC) and perigenual anterior cingulate cortex. OFC hypometabolism was not correlated with medication intake. In compliant patients, daily STS for 3 months was followed by a normalization of the fronto-temporal hypometabolism (p< 0.001; OFC: pFWE<0.01). Conclusion: Our study suggests that the OFC is hypoactive in episodic migraine. STS with the Cefaly° device is able to normalize this hypoactivity. This indicates that STS exerts its beneficial effect via slow neuromodulatory mechanisms, as also previously shown for percutaneous occipital nerve stimulation in refractory cluster headache (Magis et al., BMC Neurology 2011).
Disciplines :
Neurology
Author, co-author :
D'Ostilio, Kevin ;  Université de Liège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Thibaut, Aurore ;  Université de Liège > Centre de recherches du cyclotron
Laureys, Steven  ;  Université de Liège > Centre de recherches du cyclotron
Cosseddu, Anna ;  Université de Liège > Département des sciences biomédicales et précliniques > Neuro-anatomie
SAVA, Simona Liliana ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
GERARD, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Schoenen, Jean  ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
MAGIS, Delphine ;  Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR
Language :
English
Title :
Cerebral FDG uptake changes with supraorbital transcutaneous electrical stimulation for episodic migraine prevention
Publication date :
May 2015
Event name :
International Headache Congress
Event place :
VALENCIA, Spain
Event date :
du 14 au 17 mai 2015
Audience :
International
Available on ORBi :
since 15 July 2015

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