ORBi: Derdelinckx Inge - Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes

Reference : Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resista...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/18395

Title :	Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes
Language :	English
Author, co-author :	Derdelinckx, Inge [> > > >]
	Van Laethem, Kristel [> > > >]
	Maes, Baert [> > > >]
	Schrooten, Yoeri [> > > >]
	De Schouwer, Kirsten [> > > >]
	De Wit, Stéphane [> > > >]
	Fransen, Katrien [> > > >]
	Garcia Ribas, Sergio [> > > >]
	Moutschen, Michel [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
	Vaira, Dolorès [Centre Hospitalier Universitaire de Liège - CHU > > Immuno-hématologie >]
	Zissis, Georges [> > > >]
	Van Ranst, Marc [> > > >]
	Van Wijngaerden, Eric [> > > >]
	Vandamme, Anne-Mieke [> > > >]
Publication date :	28-Nov-2003
Journal title :	FEMS Immunology & Medical Microbiology
Publisher :	Elsevier Science Bv
Volume :	39
Issue/season :	2
Pages :	119-124
ISSN :	0928-8244
City :	Amsterdam
Keywords :	[en] human immunodeficiency virus type 1 ; resistance testing ; subtypes ; line probe assay
Abstract :	[en] In this study we evaluated the performance of the VERSANT((R)) HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared the results with population sequencing and found concordance to be in line with previous studies in treatment-experienced patients (86.87% for reverse transcriptase (RT); 92.77% for protease (PRO)). Discordance was mainly due to indeterminate reactions on LiPA (8.45% for RT; 6.85% for PRO) and minor discordances (4.13% for RT; 0.25% for PRO). Major discordances were rare (0.46% for RT; 0.12% for PRO). Indeterminate reactions were significantly associated with strains belonging to non-B subtypes. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V.. All rights reserved.
Permalink :	http://hdl.handle.net/2268/18395

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