Reference : Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resista...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/18395
Performance of the VERSANT (R) HIV-1 Resistance Assays (LiPA) for detecting drug resistance in therapy-naive patients infected with different HIV-1 subtypes
English
Derdelinckx, Inge [> > > >]
Van Laethem, Kristel [> > > >]
Maes, Baert [> > > >]
Schrooten, Yoeri [> > > >]
De Schouwer, Kirsten [> > > >]
De Wit, Stéphane [> > > >]
Fransen, Katrien [> > > >]
Garcia Ribas, Sergio [> > > >]
Moutschen, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Immunopathologie - Transplantation]
Vaira, Dolorès mailto [Centre Hospitalier Universitaire de Liège - CHU > > Immuno-hématologie >]
Zissis, Georges [> > > >]
Van Ranst, Marc [> > > >]
Van Wijngaerden, Eric [> > > >]
Vandamme, Anne-Mieke [> > > >]
28-Nov-2003
FEMS Immunology & Medical Microbiology
Elsevier Science Bv
39
2
119-124
Yes (verified by ORBi)
0928-8244
Amsterdam
[en] human immunodeficiency virus type 1 ; resistance testing ; subtypes ; line probe assay
[en] In this study we evaluated the performance of the VERSANT((R)) HIV-1 Resistance Assays (LiPA) in detecting drug resistance in therapy-naive HIV-infected patients diagnosed in Belgium in 2000. We compared the results with population sequencing and found concordance to be in line with previous studies in treatment-experienced patients (86.87% for reverse transcriptase (RT); 92.77% for protease (PRO)). Discordance was mainly due to indeterminate reactions on LiPA (8.45% for RT; 6.85% for PRO) and minor discordances (4.13% for RT; 0.25% for PRO). Major discordances were rare (0.46% for RT; 0.12% for PRO). Indeterminate reactions were significantly associated with strains belonging to non-B subtypes. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V.. All rights reserved.
http://hdl.handle.net/2268/18395

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