Reference : Molecular testing of multiple HIV-1 transmissions in a criminal case
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/18387
Molecular testing of multiple HIV-1 transmissions in a criminal case
English
Lemey, Philippe [Katholieke Universiteit Leuven - KUL > > >Rega inst. > > >]
Van Dooren, Sonia [>Univ. Antwerp > > >Dept.Social Med and Epidemiol > 2020 Antwerp > >]
Van Laethem, Kristel [> > > >]
Schrooten, Yoeri [> > > >]
Derdelinckx, Inge [> > > >]
Goubau, Patrick [> >]
Brun-Vezinet, Françoise [> > > >]
Vaira, Dolorès mailto [Centre Hospitalier Universitaire de Liège - CHU > > Immuno-hématologie >]
Vandamme, Anne-Mieke [Univ.Antwerp > Dept. Social Med and Epidemiol. > 2020 Antwerp > >]
14-Oct-2005
AIDS
Lippincott Williams & Wilkins
19
15
1649-1658
Yes (verified by ORBi)
0269-9370
Philadelphia
[en] HIV transmission ; phylogenetic analysis ; forensic investigation ; epidemiological linkage
[en] Objective: To test the a priori hypothesis of HIV-1 transmission from one suspect to six recipients in a criminal case. Methods: Partial pol and/or env sequences were obtained for at least two samples of the suspect and the victims. Appropriate local controls were sampled based on epidemiological and subtype criteria. Phylogenetic testing was performed using different reconstruction methods. Results: Phylogenetic analyses consistently inferred a monophyletic cluster for the suspect and victim samples in both genome regions. This was highly supported by parametric and non-parametric bootstrapping techniques. Moreover, the controls most closely related to the suspect-victim cluster had a similar geographical origin to the suspect. Conclusions: Taking into account the limitations on the conclusions that can be drawn from molecular investigations we could infer that our molecular data is consistent with a scenario of multiple HIV transmission between suspect and victims.
http://hdl.handle.net/2268/18387

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