Reference : Evidence of mast-cell activation in a subset of patients with eosinophilic chronic ob...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/1836
Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease
English
Louis, Renaud mailto [Université de Liège - ULg > Département des sciences cliniques > Pneumologie - Allergologie]
Cataldo, Didier mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement - Département des sciences biomédicales et précliniques]
Buckley, M. G. [> > > >]
Sele, Jocelyne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Henket, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Pneumologie-Allergologie >]
Lau, L. C. [> > > >]
Bartsch, Pierre mailto [Université de Liège - ULg > > Pneumologie-Allergologie >]
Walls, A. F. [> > > >]
Djukanovic, R. [> > > >]
Aug-2002
European Respiratory Journal
European Respiratory Society
20
2
325-331
Yes (verified by ORBi)
International
0903-1936
1399-3003
Lausanne
Switzerland
[en] asthma ; chronic obstructive pulmonary disease ; inflammatory cells ; mediators ; sputum
[en] Although asthma has been viewed mainly, as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in severe asthma and sputum eosinophilia in sonic COPD patients. In an attempt to further characterise these two syndromes according to pathology, the current authors have conducted a study of induced sputum in 15 subjects with COPD, 17 asthmatics, and 17 nonatopic healthy individuals. Sputum was analysed for cytology and levels of eosinophil cationic protein (ECP), albumin, tryptase and soluble intercellular adhesion molecule-1. The COPD subjects differed from the asthmatics as they had higher sputum neutrophil and lower columnar epithelial cell counts, but there were no differences in any soluble marker studied. When compared to control subjects, both the asthmatic and COPD subjects had raised eosinophil counts and ECP levels. In a subset of COPD subjects with Sputum eosinophilia (>3% of total cells), significantly increased levels of tryptase were detected. In conclusion, although chronic obstructive pulmonary disease is a more neutrophilic disease than asthma, the two diseases are difficult to distinguish on the basis of sputum levels of the soluble markers traditionally associated with asthma. However, a subset of patients with chronic obstructive pulmonary disease with airway eosinophilia and mast-cell activation might represent a distinct pathological phenotype.
http://hdl.handle.net/2268/1836
http://erj.ersjournals.com/content/vol20/issue2/

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