Article (Scientific journals)
Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial.
Passerieux, Emilie; Hayot, Maurice; Jaussent, Audrey et al.
2015In Free Radical Biology and Medicine, 81, p. 158-69
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Keywords :
Antioxidants; Facioscapulohumeral muscular dystrophy (FSHD); Oxidative stress; Physical performance; Radical oxygen species
Abstract :
[en] Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles. As growing evidence suggests that oxidative stress may contribute to FSHD pathology, antioxidants that might modulate or delay oxidative insults could help in maintaining FSHD muscle function. Our primary objective was to test whether oral administration of vitamin C, vitamin E, zinc gluconate, and selenomethionine could improve the physical performance of patients with FSHD. Adult patients with FSHD (n=53) were enrolled at Montpellier University Hospital (France) in a randomized, double-blind, placebo-controlled pilot clinical trial. Patients were randomly assigned to receive 500 mg vitamin C, 400mg vitamin E, 25mg zinc gluconate and 200 mug selenomethionine (n=26), or matching placebo (n=27) once a day for 17 weeks. Primary outcomes were changes in the two-minute walking test (2-MWT), maximal voluntary contraction, and endurance limit time of the dominant and nondominant quadriceps (MVCQD, MVCQND, TlimQD, and TlimQND, respectively) after 17 weeks of treatment. Secondary outcomes were changes in the antioxidant status and oxidative stress markers. Although 2-MWT, MVCQ, and TlimQ were all significantly improved in the supplemented group at the end of the treatment compared to baseline, only MVCQ and TlimQ variations were significantly different between groups (MVCQD: P=0.011; MVCQND: P=0.004; TlimQD: P=0.028; TlimQND: P=0.011). Similarly, the vitamin C (P<0.001), vitamin E as alpha-tocopherol (P<0.001), vitamin C/vitamin E ratio (P=0.017), vitamin E gamma/alpha ratio (P=0.022) and lipid peroxides (P<0.001) variations were significantly different between groups. In conclusion, vitamin E, vitamin C, zinc, and selenium supplementation has no significant effect on the 2-MWT, but improves MVCQ and TlimQ of both quadriceps by enhancing the antioxidant defenses and reducing oxidative stress. This trial was registered at clinicaltrials.gov (number: NCT01596803).
Disciplines :
Surgery
Author, co-author :
Passerieux, Emilie
Hayot, Maurice
Jaussent, Audrey
Carnac, Gilles
Gouzi, Fares
Pillard, Fabien
Picot, Marie-Christine
Bocker, Koen
Hugon, Gerald
PINCEMAIL, Joël ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Defraigne, Jean-Olivier ;  Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Verrips, Theo
Mercier, Jacques
Laoudj-Chenivesse, Dalila
More authors (4 more) Less
Language :
English
Title :
Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial.
Publication date :
2015
Journal title :
Free Radical Biology and Medicine
ISSN :
0891-5849
eISSN :
1873-4596
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
81
Pages :
158-69
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014 Elsevier Inc. All rights reserved.
Available on ORBi :
since 03 July 2015

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