Abstract :
[en] The invention is related to a method to obtain reactive [18F] fluorides in an org. medium suitable for radiolabeling without any azeotropic evapn. step, using a solid phase extn. column contg. a modified non- ionic solid support. The SS is selected from extn. resins and liq. chromatog. resins comprising polar and nonpolar phases functionalized with or made of alkyl chains comprising 1 to 30 carbon atoms, polystyrene, cyclohexyl, poly(divinylbenzene), poly(styrene-5-divinylbenzene), Ph, polyamide, aminopropyl (NH2), cyanopropyl (CN), alcs. or diols, carboxymethyl, hydroxylated poly(styrene-divinylbenzene), diethylaminoethyl, quaternary aminoethyl or sulfopropyl. Said vinyl comonomer is selected from the group consisting of vinylpyrrolidone, vinyl acetate, (methacryloyloxymethyl)naphthalene, 4,4'-bis(maleimido)diphenylmethane, p,p'-dihydroxydiphenylmethane diglycidylmethacrylic ester, p,p'-dihydroxydiphenylpropane diglycidylmethacrylic ester, 2-hydroxyethyl methacrylate (HEMA), 2,2-dimethylaminoethyl methacrylate (DMAEMA), ethylenedimethacrylate glycidyl methacrylate, N-vinylcarbazole, acrylonitrile, vinylpyridine, N-methyl-N-vinylacetamide, aminostyrene, -30-Me acrylate, Et acrylate, Me methacrylate, N-vinylcaprolactam, N-methyl-N-vinylacetamide. Said metal salt cation is selected from the alkali group, preferably lithium, sodium, potassium, rubidium and cesium, the alk. earth metal group, preferably magnesium, calcium, strontium and barium, and the ammonium cation (NH4+); - said salt is selected from the group of halogenides, preferably fluor, chlor, brome, and iode, hydroxide, carbonates, phosphates, sulfates, carboxylates, acetate, alcoholates and perchlorate; - a complexing agent is selected from the group consisting of cryptands, including kryptofixs, such as 1,4,10-Trioxa-7,13-diazacyclopentadecane, 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane, 4,7,13,16,21-Pentaoxa-1,10-diazabicyclo[8.8.5]tricosane, 4,7,13,18-Tetraoxa-1,10-diazabicyclo[8.5.5]eicosane, 5,6-Benzo-4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacos-5-ene.
