Article (Scientific journals)
Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids.
Riva, Laura; Thiry, Marc; Lebrun, Marielle et al.
2014In Journal of Virology
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Keywords :
Varicella zoster virus; nuclear egress
Abstract :
[en] The protein encoded by the ORF9 is essential for Varicella-zoster virus (VZV) replication. Previous studies documented its presence in the trans-Golgi network and its involvement in secondary envelopment. In this work, we deleted the ORF9p acidic cluster, destroying its interaction with ORF47p and resulting in a nuclear accumulation of both proteins. This phenotype results to an accumulation of primary enveloped capsids in the perinuclear space, reflecting a capsid de-envelopment defect.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Riva, Laura ;  Université de Liège - ULiège > Département des Sciences de la Vie > GIGA-R Virologie et Immunologie
Thiry, Marc  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie cellulaire
Lebrun, Marielle  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
L'Homme, Laurent ;  Université de Liège - ULiège > GIGA-R : Virologie - Immunologie
Piette, Jacques ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie
Sadzot-Delvaux, Catherine ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
Language :
English
Title :
Deletion of the ORF9p acidic cluster impairs the nuclear egress of Varicella-zoster virus capsids.
Publication date :
2014
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2014, American Society for Microbiology. All Rights Reserved.
Available on ORBi :
since 26 June 2015

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