Article (Scientific journals)
Inflammasome NLRP3 et graisse viscerale.
ESSER, Nathalie; Legrand-Poels, Sylvie; Piette, Jacques et al.
2014In Revue Médicale de Liège, 69 Spec No, p. 57-61
Peer reviewed
 

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Keywords :
Carrier Proteins/physiology; Humans; Inflammasomes; Intra-Abdominal Fat/immunology; Obesity/immunology
Abstract :
[en] It is recognized that abdominal obesity is accompanied by a chronic low-grade inflammation that is involved in the pathogenesis of insulin resistance and type 2 diabetes. Metabolic syndrome and type 2 diabetes are associated with an abnormal production of pro-inflammatory cytokines, an increased level of acute-phase proteins and an activation of inflammatory signalling pathways. These pro-inflammatory cytokines, mainly produced by adipose tissue macrophages, are involved in development of obesity-associated insulin resistance and in the progression from obesity to type 2 diabetes. Particularly, the interleukin-1 beta may play a key role through the activation of the NLRP3 inflammasome. Adipose tissue topography, more than the total amount of fat, may play an important pathogenic role. Indeed, the presence of metabolic abnormalities in obesity is associated with a deleterious immunological and inflammatory profile of visceral adipose tissue and with an increased activation of the NLRP3 inflammasome in macrophages infiltrating visceral adipose tissue. Targeting inflammation, especially NLRP3 inflammasome, may offer potential novel therapeutic perspectives in the prevention and treatment of type 2 diabetes.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
ESSER, Nathalie  
Legrand-Poels, Sylvie ;  Université de Liège > GIGA-R : Virologie - Immunologie
Piette, Jacques ;  Université de Liège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie
Paquot, Nicolas ;  Université de Liège > Département des sciences de la santé publique > Nutrition
Scheen, André  ;  Université de Liège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques
Language :
French
Title :
Inflammasome NLRP3 et graisse viscerale.
Alternative titles :
[en] NLRP3 inflammasome and visceral adipose tissue
Publication date :
2014
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
69 Spec No
Pages :
57-61
Peer reviewed :
Peer reviewed
Additional URL :
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