Paper published in a book (Scientific congresses and symposiums)
Galectin-3 and Suppression of Tumorigenicity 2 measurement in participants at the “Tor des Géants”
LE GOFF, Caroline; Kaux, Jean-François; Gergelé, Laurent et al.
2015In Radmann, A; Hedenborg, S; Tsolakidis, E (Eds.) 20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS0th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS
Peer reviewed
 

Files


Full Text
Galectin 3 ECSS 2015.pdf
Author postprint (3.69 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Introduction: Gal-3 is a carbohydrate binding lectin produced by macrophages, upregulated in hypertrophied heart, emerging as a mediator for fibrosis development and cardiac remodeling. ST2 is a family member of IL-1 receptors initially known for its role in immunological processes. It has a potential role in the cardiac pathogenesis. These receptors are led in cardiomyocytes and fibroblasts due to a mechanical stress. We aimed to examine the evolution of Gal-3 and ST2 in trailers who ran one of the most challenging ultra-marathon in the world: the Tor des Géants (330 km, altitude range: 24000m). Methods: Levels of plasma Gal-3 and ST2 were determined at 4 times: before the start, after 158km, at the end and 3 days after the end of the race in 33 trailers. Samples were directly centrifuged and frozen at -80°C. Gal-3 measurement was performed on the VIDAS (Biomerieux) and ST2 was analyzed with the Presage ST2 Assay (Critical Diagnostic). The reference values are <17.8ng/mL for Gal-3 and <35ng/mL for ST2. Statistica was used for the statistical analysis (ANOVA). We calculated the difference between the different time and expressed in delta: Δ1=(T2-T1)/T1*100, Δ2=(T3-T2)/T2*100, Δ3=(T4-T3)/T3*100, Δ4=(T3-T1)/T1*100, Δ5=(T4-T1)/T1*100. After that, we tried to correlate the delta between them (results= R(p-value)). Results were considered as significant with p<0.05. Results: Plasmatic levels of Gal-3 did never exceed the cut-off of 17.8ng/mL, except for 1 trailer in T2. A slight increase of levels of Gal-3 was observed at T2 (min-max:7.5-17.6ng/mL). These ones did not vary a lot at T3 (min-max:7.0- 18.8ng/mL) but return to normality at T4 (min-max:6.0-12.8ng/mL). For ST2, at T1, 12 subjects had plasmatic levels above the reference value of 35ng/ml. At T2, only 2 trailers blood samples were still in the reference interval. Indeed, a great increase of ST2 plasmatic levels observed (min-max:18.8-158.8ng/mL). A slight decrease of ST2 levels was observed at T3, but only one subject had a value below 30ng/ml (min-max:20.1-182.7ng/mL). However, a subject had still plasmatic levels above T2 values. A return to normality was observed at T4 with 16 trailers blood levels in the reference interval (min-max:12.0-56.4ng/mL). We observed an increase for Gal-3 and ST2, above the reference values only for ST2. We noted for both a decrease up to the normal values 3 days after the trail. For the correlation between deltas, we observed that Gal-3 and ST2 are correlated for each delta. Discussion: A logical correlation is observed between Gal-3 andST2 as they are involved in cardiac fibrosis and inflammation. But we do not known why it is not in the same proportion. We know that some trailers take NSAIDs and painkillers during the race. The results of this study demonstrate that this exercise was associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure as fibrosis. However, ST2 values were higher, perhaps due to a mechanical stress more than a cardiac stress. Gal-3 is perhaps then more cardiospecific than ST2.
Disciplines :
Orthopedics, rehabilitation & sports medicine
Laboratory medicine & medical technology
Author, co-author :
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie clinique
Kaux, Jean-François  ;  Université de Liège > Département des sciences de la motricité > Département des sciences de la motricité
Gergelé, Laurent
Millet, Grégoire
Viallon, Marie
Croisille, Pierre
Cavalier, Etienne  ;  Université de Liège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Galectin-3 and Suppression of Tumorigenicity 2 measurement in participants at the “Tor des Géants”
Publication date :
June 2015
Event name :
20th Annual Congress of the European College of Sport Science0th Annual Congress of the European College of Sport Science
Event organizer :
ECSS
Event place :
Malmö, Sweden
Event date :
24-27th June 20154-27th June 2015
Audience :
International
Main work title :
20th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS0th annual Congress of the EUROPEAN COLLEGE OF SPORT SCIENCE - BOOK OF ABSTRACTS
Author, co-author :
Radmann, A
Hedenborg, S
Tsolakidis, E
ISBN/EAN :
978-91-7104-567-6
Pages :
435-436
Peer reviewed :
Peer reviewed
Available on ORBi :
since 24 June 2015

Statistics


Number of views
111 (2 by ULiège)
Number of downloads
4 (1 by ULiège)

Bibliography


Similar publications



Contact ORBi