“Product-oriented engineering” applied to the development of porous scaffolds for tissue engineering

de Bien, Charlotte; Ounally, T; Collard, Valérie; Jérôme, Christine; Léonard, Angélique; Toye, Dominique

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“Product-oriented engineering” applied to the development of porous scaffolds for tissue engineering

de Bien, Charlotte; Ounally, T; Collard, Valérie et al.

2014 • In World Congress in Industrial Process Tomography

Peer reviewed

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https://hdl.handle.net/2268/183148

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Keywords :

Biopolymer porous scaffolds; Microstructure 3D; Permeability; Polylactic acid; Tissue engineering; X-ray microcomputed tomography; Young’s modulus; Computerized tomography; Elastic moduli; Mechanical permeability; Microstructure; Polyesters; Polymer blends; Scaffolds (biology); Tissue; Tomography; End-use properties; Freeze-drying process; Microcomputed tomography; Operating condition; Poly lactic acid; Porous scaffold; Tension compressions; X ray microtomography

Abstract :

[en] This work applies a “product-oriented engineering” approach to the development of porous scaffolds for tissue engineering. Polylactic acid scaffolds were obtained by a freeze-drying process. Their 2D/3D microstructure was characterized by X-ray microtomography and related to the operating conditions used. Two types of scaffold end-use properties were characterized in relation to their microstructure: the mechanical and the transport properties. Scaffold young's modulus was computed from data measured on tension-compression devices. To evaluate the permeability, Darcy’s experiments were carried out. The obtained results allowed highlighting the quantitative relationships existing between elaboration conditions, microstructure and end-use properties of the fabricated PLA scaffolds. © 2014 International Society for Industrial Process Tomography.

Disciplines :

Chemical engineering

Author, co-author :

de Bien, Charlotte ; Université de Liège > Département de chimie appliquée > Génie chimique - Procédés et développement durable

Ounally, T

Collard, Valérie ; Université de Liège > Centre d'études et de rech. sur les macromolécules (CERM)

Jérôme, Christine ; Université de Liège > Département de chimie (sciences) > Chimie des macromolécules et des matériaux organiques (CERM)

Léonard, Angélique ; Université de Liège > Département de chimie appliquée > Génie chimique - Procédés et développement durable

Toye, Dominique ; Université de Liège > Département de chimie appliquée > Génie de la réaction et des réacteurs chimiques

Language :

English

Title :

“Product-oriented engineering” applied to the development of porous scaffolds for tissue engineering

Publication date :

2014

Event name :

7th World Congress in Industrial Process Tomography

Event place :

Krakow, Poland

Event date :

du 02 septembre 2013 au 05 septembre 2013

Journal title :

World Congress in Industrial Process Tomography

Peer reviewed :

Peer reviewed

Available on ORBi :

since 23 June 2015

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