Article (Scientific journals)
Inverse Finite Element Modeling for Characterization of Local Elastic Properties in Image-Guided Failure Assessment of Human Trabecular Bone
Zwahlen, Alexander; Christen, David; Ruffoni, Davide et al.
2015In Journal of Biomechanical Engineering, 137 (1)
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Abstract :
[en] The local interpretation of microfinite element (mu FE) simulations plays a pivotal role for studying bone structure-function relationships such as failure processes and bone remodeling. In the past mu FE simulations have been successfully validated on the apparent level however, at the tissue level validations are sparse and less promising. Furthermore, intratrabecular heterogeneity of the material properties has been shown by experimental studies. We proposed an inverse mu FE algorithm that iteratively changes the tissue level Young's moduli such that the mu FE simulation matches the experimental strain measurements. The algorithm is setup as a feedback loop where the modulus is iteratively adapted until the simulated strain matches the experimental strain. The experimental strain of human trabecular bone specimens was calculated from time-lapsed images that were gained by combining mechanical testing and synchrotron radiation microcomputed tomography (SR mu CT). The inverse mu FE algorithm was able to iterate the heterogeneous distribution of moduli such that the resulting mu FE simulations matched artificially generated and experimentally measured strains.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Zwahlen, Alexander;  Muller, R (Reprint Author), ETH, Inst Biomech, Vladimir Prelog Weg 3, CH-8093 Zurich, Switzerland. Zwahlen, Alexander
Christen, David;  Christen, David
Ruffoni, Davide  ;  Université de Liège > Département d'aérospatiale et mécanique > Mécanique des matériaux biologiques et bioinspirés
Schneider, Philipp;  Schneider, Philipp
Schmoelz, Werner;  Mueller, Ralph, ETH, Inst Biomech, CH-8093 Zurich, Switzerland. Schmoelz, Werner, Med Univ Innsbruck, Dept Trauma Surg, A-6020 Innsbruck, Austria.
Mueller, Ralph
Title :
Inverse Finite Element Modeling for Characterization of Local Elastic Properties in Image-Guided Failure Assessment of Human Trabecular Bone
Publication date :
2015
Journal title :
Journal of Biomechanical Engineering
ISSN :
0148-0731
eISSN :
1528-8951
Publisher :
ASME
Volume :
137
Issue :
1
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Article
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