electron paramagnetic resonance; Ru(II) complexes; anticancer properties
Abstract :
[en] Fight against cancer is a priority of today’s research. Since the discovery of the anticancer properties of cisplatin (CisPt) in 1965 by Rosenberg [1], the treatment of cancer by chemotherapy has known great improvements. Unfortunately, CisPt has several side effects and is not effective against all kinds of cancer. Nevertheless its use highlights the great potential of organometallic compounds in the treatment of cancer [2]. Here we investigated the potential anticancer properties of two new organometallic compounds based on ruthenium II : [RuCl(p-cymene)(S2C.IDip)]+(PF6)- and [RuCl(p-cymene)(S2C.ICy)]+(PF6)-, named as LDO436 and LDO437 respectively.
Research center :
Laboratoire de spectroscopie biomédicale, CORD
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Collienne, Simon ; Université de Liège > Département de physique > Spectroscopie biomédicale
Terrak, Mohammed ; Université de Liège > Centre d'ingénierie des protéines
Mouithys-Mickalad, Ange ; Université de Liège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Delaude, Lionel ; Université de Liège > Département de chimie (sciences) > Chimie organométallique et catalyse homogène
Hoebeke, Maryse ; Université de Liège > Département de physique > Spectroscopie biomédicale
Language :
English
Title :
Electron paramagnetic resonance and fluorescence studies on potential anticancer properties of two new Ru(II) complexes : preliminary results
Alternative titles :
[fr] Etude par spectroscopies de résonance paramagnétique électronique et de fluorescence des potentielles propriétés anticancéreuses de deux nouveaux complexes Ru(II) : résultats préliminaires
