ORBi: Pierard Luc - Prognostic significance of a low peak serum creatine kinase level in acute myocardial infarction

Reference : Prognostic significance of a low peak serum creatine kinase level in acute myocardial in...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology Human health sciences : Cardiovascular & respiratory systems
	To cite this reference:	http://hdl.handle.net/2268/18283

Title :	Prognostic significance of a low peak serum creatine kinase level in acute myocardial infarction
Language :	English
Author, co-author :	Pierard, Luc [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
	Dubois, Christophe [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
	Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
	Chapelle, Jean-Paul [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
	Carlier, J. [> > > >]
	Kulbertus, Henri [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Publication date :	1989
Journal title :	American Journal of Cardiology
Publisher :	Elsevier Science
Volume :	63
Issue/season :	12
Pages :	792-6
Audience :	International
ISSN :	0002-9149
City :	New York
Country :	NY
Keywords :	[en] Clinical Enzyme Tests ; Creatine Kinase/blood ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis/mortality ; Prognosis ; Time Factors
Abstract :	[en] To assess the prognostic significance of a low peak creatine kinase (CK) level, 723 consecutive patients admitted with acute myocardial infarction (AMI) within 16 hours after onset of symptoms were studied. Thrombolytic therapy was not attempted during the study. Patients were dichotomized according to their peak CK levels, determined from a cluster analysis of peak CK distribution among the population of patients who died within 3 years after hospital discharge. The 139 patients with low peak CK (less than or equal to 650 IU/liter) (group 1) were compared to the 584 patients with high peak CK (greater than 650 IU/liter) (group 2). Patients in group 1 were older and had a higher incidence of previous AMI, angina pectoris before AMI and non-Q-wave AMI. Despite a lower incidence of in-hospital complications and a nonsignificantly lower hospital mortality rate (4 vs 9%) the group 1 three-year posthospital mortality rate was higher (26 vs 17%; p less than 0.02), especially in the subgroup of patients with a Q-wave infarct (mortality 31% in group 1 vs 16% in group 2; p less than 0.001). Among the 491 patients who had a first Q-wave AMI, 55 had a peak CK less than or equal to 650 IU/liter. Compared to the 436 patients with a higher peak CK, these 55 patients had a higher incidence of early postinfarction angina (31 vs 14%; p less than 0.01), a similar hospital mortality (4 vs 7%) but a higher 3-year posthospital mortality (23 vs 12%; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Permalink :	http://hdl.handle.net/2268/18283
	also: http://hdl.handle.net/2268/34685

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